Evidence map›Paper›PMID 42036048›Full record

ArticleThe Journal of biological chemistry2026

A novel synthetic melanin as a potential anticancer agent that induces apoptosis and cyclin D downregulation through distinct pathways.

Yoshiyuki Kawamoto, Yui Furuhashi, Silvi Zakiyatul Ilmiyah, Seiji Yamaguchi, Nozomi Nishimura, Riko Iwata, Arisa Imoto, Takashi Murate, Yuhsuke Ohmi, Sofy Permana and 7 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Yoshiyuki KawamotoDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan. Electronic address: ykawa@fsc.chubu.ac.jp.
Yui FuruhashiDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
Silvi Zakiyatul IlmiyahDoctoral Program in Medical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Seiji YamaguchiDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
Nozomi NishimuraDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
Riko IwataDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
Arisa ImotoDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
Takashi MurateDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
Yuhsuke OhmiDepartment of Clinical Engineering, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.
Sofy PermanaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, Indonesia.
Agustina Tri EndhartiDepartment of Clinical Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Yuki UenoDepartment of Health and Nutritional Sciences, Faculty of Health Sciences, Aichi Gakuin University, Nisshin, Aichi, Japan.
Machiko IidaDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan; Department of Disease Model, Institute For Developmental Research, Aichi Developmental Disability Center, Kasugai, Aichi, Japan.
Ichiro YajimaDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan; Unit of Molecular and Cellular Toxicology, Department of Bioscience and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, Saitama, Japan.
Nobutaka OhgamiDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan; Department of Hygiene, Fujita Heath University School of Medicine, Toyoake, Aichi, Japan.
Masashi KatoDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Kozue TakedaDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite extensive development of anticancer agents, there remains a critical need for therapeutics with novel mechanisms of action. This study reports the potent anticancer activity and mechanistic analysis of highly water-soluble dopa-melanin (DM) prepared through a unique synthetic process. DM exhibits distinctive structural and chemical properties that contribute to its exceptional aqueous solubility (≥50 mg/ml) and may underlie its enhanced biological activity. DM reduced cell viability in multiple cancer cell lines. Using HeLa cells as a representative model, DM suppressed cell migration and three-dimensional growth. Fractionation revealed that activity was associated with polymers larger than 30 kDa, suggesting a critical role for high-molecular-weight species. Mechanistic studies showed that DM induced S/G

Indexed as

Antineoplastic AgentsApoptosisCyclin DDown-RegulationMelaninsAnimalsCell Line, TumorCell ProliferationCell SurvivalDrug Screening Assays, AntitumorHumansMiceAntineoplastic AgentsCyclin DMelaninsanticancer drugapoptosiscalpaincyclin Dproteolysis

Identifiers

PMID42036048
PMCPMC13197775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.