Evidence map›Paper›PMID 42036043›Full record

ArticleThe Journal of biological chemistry2026

A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks.

Alicia Llorente, Gurpreet K Arora, Ryan M Loughran, Rabi Murad, Svetlana Maurya, Sophia Crabtree, Benji Portillo, Pratima Chapagain, Hundaol Huluka, Scott Eron and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alicia LlorenteCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
Gurpreet K AroraCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
Ryan M LoughranCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
Rabi MuradBioinformatics Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
Svetlana MauryaProteomics Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
Sophia CrabtreeCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
Benji PortilloFlow Cytometry Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
Pratima ChapagainDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, USA.
Hundaol HulukaDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, USA.
Scott EronLarkspur Biosciences, Cambridge, USA.
Krista GoodmanLarkspur Biosciences, Cambridge, USA.
Guosen YeLarkspur Biosciences, Cambridge, USA.
Raymond D BlindDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, USA.
Brooke M EmerlingCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA. Electronic address: bemerling@sbpdiscovery.org.

Funding

MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9M
Function and Mechanism of the Hippo-PI5P4K Axis for Growth ControlR01GM143583 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI EMERLING, BROOKE M. · 2022 to 2025
$2.2M
NIDDK NIH HHS T32 DK007563NIGMS NIH HHS R01 GM143583
6 · The paper itself

Abstract

Phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks) have emerged as candidate drug targets in cancer, neurological, inflammatory, and infectious diseases. Although their canonical function is to phosphorylate PI(5)P to generate PI(4,5)P

Indexed as

Phosphotransferases (Alcohol Group Acceptor)HeLa CellsHumans1-phosphatidylinositol-4-phosphate 5-kinasePhosphotransferases (Alcohol Group Acceptor)

Identifiers

PMID42036043
PMCPMC13218151

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.