ArticleAmerican journal of obstetrics and gynecology2026
Early pregnancy oxylipin markers of inflammation and oxidative stress are associated with small-for-gestational-age birth and specific phenotypes of fetal growth restriction.
Article in American journal of obstetrics and gynecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFetal growth restriction places the fetus at risk for stillbirth, perinatal mortality, and severe morbidity, yet the disease remains difficult to diagnose, predict, and treat. Homeostasis of inflammation and oxidative stress is critical to the establishment of a healthy pregnancy, and biomarkers of these processes could contribute to these goals. Oxylipins are derived from polyunsaturated fatty acids and act as key mediators of this homeostasis and thus may be promising tools for understanding the etiology of fetal growth restriction and possible therapeutic targets.
objectiveExamine the association between early-pregnancy oxylipin biomarkers of inflammation and oxidative stress and small-for-gestational-age anfd large-for-gestational-age birth as well as ultrasound-based phenotypes of fetal growth restriction. STUDY
designIn a case-cohort study of small-for-gestational-age and large-for-gestational-age births (N=901), we measured 24 oxylipins in plasma and urine collected at ∼10 weeks' gestation. We examined associations between oxylipins and small-for-gestational-age (n=248) and large-for-gestational-age birth (n=241) as our primary endpoints. As a secondary approach, we explored associations between oxylipins and phenotypes of small-for-gestational-age and large-for-gestational-age births that were characterized based on longitudinal fetal growth measures.
resultsA primary urinary metabolite of the proinflammatory thromboxane-A
conclusionAssociations between circulating oxylipins in early pregnancy and small-for-gestational-age birth may reflect disturbances in the balance of inflammation and oxidative stress, processes that are critical to the establishment of pregnancy and healthy fetal growth. These associations differed based on small-for-gestational-age phenotype, that is, early-pregnancy vs late-pregnancy growth restriction, providing possible insights into distinct etiologies. Oxylipins may be useful targets for early prediction and/or intervention on fetal growth restriction.
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