Dual-frequency ultrasound-assisted extraction of Pongamia pinnata (L.) Pierre polysaccharides: Process optimization, structural characterization, and anti-nephrolithiatic effects.

Linhu Liu, Liao Peng, Qingyan Li, Yucheng Ma, Jianyu Liu, Kunjie Wang, Min Zhao

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Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Linhu LiuDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Liao PengDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Qingyan LiState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Yucheng MaDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Jianyu LiuDepartment of Neurology, Medical Research Center, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, China. Electronic address: jianyu_liu@swjtu.edu.cn.

Kunjie WangDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: wangkj@scu.edu.cn.

Min ZhaoDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: eyoung0801@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pongamia pinnata (L.) Pierre is a versatile plant widely recognized for its medicinal, industrial, and ecological benefits. To facilitate its comprehensive utilization, this study employed dual-frequency ultrasound-assisted extraction (DUAE) combined with response surface methodology (RSM) to optimize the extraction process for polysaccharides from P. pinnata (PPP). Under the optimal conditions (ultrasonic power of 550 W, extraction time of 17 min, and liquid/solid ratio of 40 mL/g), the maximum yield of PPP was 9.17 ± 0.24 mg/g. PPP was further purified using ion-exchange and gel filtration chromatography to obtain an active polysaccharide PPPa. The structural characteristics and anti-nephrolithiatic activity of PPPa were then thoroughly evaluated. PPPa (M

Indexed as

MillettiaPlant ExtractsPolysaccharidesUltrasonic WavesAnimalsChemical FractionationMaleMiceMice, Inbred C57BLNephrolithiasisPlant ExtractsPolysaccharidesAnti-nephrolithiatic effectsDual-frequency ultrasound-assisted extractionPolysaccharidesPongamia pinnata (L.) PierreProcess optimizationStructural analysis

Identifiers

PMID42035733

DOI10.1016/j.ultsonch.2026.107866

PMCPMC13133954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.