Evidence map›Paper›PMID 42035529›Full record

ArticlePoultry science2026

TIAM2 and ADCY7 polymorphisms and their association with feed efficiency in Huaibei partridge chickens.

Sihua Jin, Zihao Tang, Lianzhen Lu, Liang Chang, Haoming Chang, Zhitong Li, Yunxia He, Zhaoyu Geng, Shuang Gu

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Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Sihua JinCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; Anhui Provincial Key Laboratory of Local Animal Genetic Resources Protection and Bio-Breeding, Hefei 230036, China.
Zihao TangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; Anhui Provincial Key Laboratory of Local Animal Genetic Resources Protection and Bio-Breeding, Hefei 230036, China.
Lianzhen LuCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Liang ChangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Haoming ChangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Zhitong LiCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Yunxia HeCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; Anhui Provincial Key Laboratory of Local Animal Genetic Resources Protection and Bio-Breeding, Hefei 230036, China.
Zhaoyu GengCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; Anhui Provincial Key Laboratory of Local Animal Genetic Resources Protection and Bio-Breeding, Hefei 230036, China.
Shuang GuCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China; Anhui Provincial Key Laboratory of Local Animal Genetic Resources Protection and Bio-Breeding, Hefei 230036, China. Electronic address: gus@ahau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feed accounts for about 70% of poultry production costs, highlighting the importance of improving feed efficiency. TIAM2 and ADCY7 are potential regulators of feed efficiency and energy metabolism, but their associations with feed efficiency traits in poultry remain unclear. Huaibei partridge chicken, a slow-growing indigenous Chinese breed with notable meat quality and superior disease resistance, has received limited attention in feed efficiency research. This study aimed to identify single nucleotide polymorphisms (SNPs) in TIAM2 and ADCY7 and investigate their associations with feed efficiency traits in Huaibei partridge chickens. Using mixed-pool sequencing and restriction enzyme digestion, we identified the single-nucleotide polymorphisms in TIAM2 (A105910C and T166125C) and ADCY7 (A1391G and T32560C). The AC genotype of TIAM2 A105910C exhibited a significantly higher residual feed intake (RFI), an indicator of feed efficiency independent of body weight and growth rate, than the CC genotype (P < 0.05), and the T166125C TT genotype showed a higher RFI than the CC genotype (P < 0.05). In ADCY7, both GG and AG genotypes at A1391G had a higher RFI than AA genotypes (P < 0.05), whereas the T32560C TT genotype showed a significantly higher RFI than CC (P < 0.01). Combined genotype analysis revealed that the AC-TT-GG-TC combination led to a significantly higher RFI than the CC-TC-TC-GG-TC combination (P < 0.05), indicating that CC-TC-GG-TC is the predominant genotype for high feed efficiency. These findings demonstrate that TIAM2 and ADCY7 are involved in the feed efficiency. The identified SNPs and combined genotypes might serve as molecular markers for marker-assisted selection to enhance feed efficiency in the poultry industry.

Indexed as

Adenylyl CyclasesAvian ProteinsChickensEnergy MetabolismPolymorphism, Single NucleotideAminoacyltransferasesAnimalsGenotypeAdenylyl CyclasesAminoacyltransferasesAvian Proteinsglutaminyl-peptide cyclotransferaseADCY7ChickenFeed efficiencyPolymorphismTIAM2

Identifiers

PMID42035529
PMCPMC13129384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.