Evidence map›Paper›PMID 42035492›Full record

ReviewImmunoHorizons2026

Nasal humoral immunity: the first line of protection against respiratory pathogens.

Lena Hansen, Jenna J Guthmiller

Abstract readReview
In one paragraph

Review in ImmunoHorizons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ASPIRE to new horizons.ImmunoHorizons · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lena HansenDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Jenna J GuthmillerDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.ORCID 0000-0001-7566-3536

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
NIH HHS 75N93019C00051ODCDC CDC HHS 75N93019C00051
6 · The paper itself

Abstract

The nasal cavity is the first site of infection for respiratory pathogens, and control of pathogens at this site is critical for limiting disease progression. Mucosal immunity in the respiratory tract has historically been studied in the lungs despite lung infections typically arising as a result of lack of pathogen control in the upper respiratory tract. However, the generation of vaccines to prevent infection and block transmission requires an understanding of how immune responses are generated and maintained within the nasal cavity. Recently, a concerted research effort to understand immune responses in the nasal cavity and upper respiratory tract has revealed new insight into how local immune responses are generated and help to control respiratory pathogens. Here, we discuss these recent advances and outstanding questions in our understanding of humoral immunity within the nasal cavity and upper respiratory tract.

Indexed as

Immunity, HumoralNasal CavityRespiratory Tract InfectionsAnimalsHumansImmunity, Mucosalantibodieshumoral immunityplasma cells

Identifiers

PMID42035492
PMCPMC13110860

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.