Evidence map›Paper›PMID 42035491›Full record

ReviewImmunoHorizons2026

Living rent free in your head: resident memory T cells.

Hanna N Degefu, Sierra A Kleist, Pamela C Rosato

Abstract readReview
In one paragraph

Review in ImmunoHorizons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ASPIRE to new horizons.ImmunoHorizons · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hanna N DegefuDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States.
Sierra A KleistDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States.
Pamela C RosatoDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, United States.ORCID 0000-0001-7909-3868

Funding

Therapeutically harnessing anti-viral resident memory T cells in solid tumorsR01CA269455 · NCI · DARTMOUTH COLLEGE · PI Pamela Rosato · 2023 to 2026
$2.1M
National Institute of Allergy and Infectious Disease K22AI148508NCI NIH HHS R01 CA269455NIA NIH HHS R01AG78761
6 · The paper itself

Abstract

Tissue-resident memory T cells (TRM) are a distinct subset of memory T cells that persist long-term within non-lymphoid tissues and provide rapid, localized immune protection. The central nervous system (CNS) was among the first sites in which these TRM were detected, but only recently has their importance in brain immune surveillance been fully appreciated. Despite their relative low abundance, brain TRM can protect against reinfection, contribute to neuropathology, and participate in neurologic diseases. This review provides an overview of what is currently known about TRM in the brain, with a focus on CD8+ T cells, identifies major knowledge gaps, and highlights implications for human brain TRM biology. Addressing these gaps will help contextualize brain TRM in health and disease and guide strategies to harness or modulate them for vaccination and neuroimmune therapies.

Indexed as

BrainCD8-Positive T-LymphocytesImmunologic MemoryMemory T CellsAnimalsHumansVaccinationinfectionsmemoryneuroimmunologyT cellsvaccination

Identifiers

PMID42035491
PMCPMC13110863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.