Evidence map›Paper›PMID 42035387›Full record

ReviewDiscover nano2026

Biomimetic nanovesicles and nanotechnology for oral and maxillofacial diseases.

Jiayu Sun, Shaolun Tang, Jiale Yan, Jingwei Wang, Rushui Bai, Xing Wang, Bing Han, Tingting Yu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiayu Sun *Department of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, People's Republic of China.
Shaolun Tang *Department of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, People's Republic of China.
Jiale Yan *Department of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, People's Republic of China.
Jingwei WangDepartment of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, People's Republic of China.
Rushui BaiDepartment of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, People's Republic of China.
Xing WangInstitute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China. wangxing@iccas.ac.cn.
Bing HanDepartment of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, People's Republic of China. kqbinghan@bjmu.edu.cn.
Tingting YuDepartment of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, People's Republic of China. tingtingyu@bjmu.edu.cn.

Funding

Beijing Municipal Science Technology Commission Z211100002921066Beijing Natural Science Foundation F252067Beijing Physician Scientist Training Project BJPSTP-2025-01National Key Research and Development Program of China 2022YFA1206100National Key Research and Development Program of China 2024YFC2510702National Natural Science Foundation of China 52373123National Natural Science Foundation of China U21A2055
6 · The paper itself

Abstract

Oral and maxillofacial diseases, such as dental caries, periodontal disease, and tissue defects, demonstrate limited therapeutic effect due to the oral cavity's complex microecological environment, intractable chronic inflammation, and the challenge of regenerating dental and periodontal tissues. Biomimetic nanovesicles (BNVs), including extracellular vesicles (EVs) and artificial nanovesicles (ANVs), play a beneficial therapeutic role in these diseases. BNVs are capable of delivering a variety of therapeutic agents, including RNAs, proteins, drugs, and nanoparticles, with their efficiency, specificity, and safety enhanced by nanotechnological modification and engineering. This review provides a comprehensive overview of BNV classification and characterization, summarizes their functional advantages in disease treatment, and highlights their applications in oral and maxillofacial disorders, particularly in microbiome modulation, immunoinflammatory regulation, and tissue regeneration. The opportunities and challenges of translating BNVs into clinical practice are also assessed.

Indexed as

Biomimetic nanovesiclesInflammationNanotechnologyOral and maxillofacial diseasesRegeneration

Identifiers

PMID42035387
PMCPMC13111752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.