Evidence map›Paper›PMID 42035111›Full record

ArticleJournal of nanobiotechnology2026

A NIR-IIb-excited capsule endoscope enabling high-contrast fluorescence imaging via spectrally-isolated detection for early-stage gastrointestinal cancer.

Weicheng Wang, Qichao Li, Yuming Yang, Wei Wang, Jinlei Jiang, Mianyi Xiang, Chunlei Jiang, Qirui Zhao, Xinyuan Cui, Shengsheng Cui and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Weicheng WangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Qichao LiState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China. liqichao@sjtu.edu.cn.
Yuming YangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Wei WangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Jinlei JiangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Mianyi XiangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Chunlei JiangCollege of Electrical and Information Engineering, Northeast Petroleum University, Daqing, 163318, P.R. China.
Qirui ZhaoMedical and Engineering Cross Research Institute, the First Affiliated Hospital of Henan University, Kaifeng, 475004, P.R. China.
Xinyuan CuiDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin 2nd Rd, Shanghai, 200025, P. R. China.
Shengsheng CuiSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Ning TangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Binyu ZhuSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Mingrui ChenSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Yongyi XuSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Cheng ZhouSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China. zhou-cheng@sjtu.edu.cn.
Daxiang CuiSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China. dxcui@sjtu.edu.cn.

Funding

Innovation Group Project of National Natural Science Foundation of China No.81921002National Key Research and Development Program of China No. 2017FYA0205301Natural Science Foundation of Shanghai No. 22ZR1467600Project of International Cooperation and Exchanges of the National Natural Science Foundation of China No. 82020108017Projects of Shanghai Science and Technology Commission 21DZ2203200
6 · The paper itself

Abstract

Early detection of gastrointestinal cancers faces significant challenges, mainly including the invasiveness of wired endoscopes, the limited tissue penetration depth of white light capsule endoscopy (CE), and the low signal-to-noise ratio (SNR) and contrast caused by excitation light interference in traditional fluorescence imaging CE. Herein, we developed a near-infrared-IIb (NIR-IIb) window-excited fluorescence imaging capsule endoscope (FICE) for the high-contrast diagnosis of early-stage gastrointestinal cancers. The FICE employs a 1550-nm central wavelength NIR-IIb laser diode to precisely shape the excitation beam for selective activation of upconversion nanoprobes (UCNPs) aggregates in lesion tissues, stimulating them to emit 540 nm green fluorescence-the most sensitive wavelength for CMOS imaging chips. Utilizing 1550 nm excitation light facilitates enhanced penetration into biological tissues and the detection method with an excitation-emission spectral separation of more than 1000 nm effectively eliminates background interference, thereby yielding diagnostic images with ultrahigh SNR and superior contrast. Proof-of-concept experiments in nude mice demonstrated that this FICE achieved specific fluorescence detection of subcutaneous and colonic mucosal tumors with a penetration depth of up to 6 mm and fluorescence-to-background contrast ratios exceeding 90%. Ex vivo validation in porcine tissues confirmed the FICE's imaging capability within realistic anatomical environments. Furthermore, we designed a wireless power supply and posture control system to provide continuous energy and precise motion control for the FICE. To our knowledge, this paper presents the first NIR-IIb-excited FICE, offering a non-invasive, high-contrast and high-SNR diagnostic tool for early gastrointestinal cancer detection and demonstrating remarkable clinical potential.

Indexed as

Capsule EndoscopesGastrointestinal NeoplasmsOptical ImagingAnimalsCell Line, TumorEarly Detection of CancerHumansInfrared RaysMiceMice, NudeSignal-To-Noise RatioCapsule endoscopeEarly-Stage Gastrointestinal cancerHigh-Contrast Fluorescence imagingNIR-IIb-Excited

Identifiers

PMID42035111
PMCPMC13255310

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.