ArticleJournal of cardiothoracic surgery2026
Comorbidities as predictors of postoperative pulmonary complications after lung cancer surgery.
Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Risk factors and outcomes of postoperative pneumonia in non-small cell lung cancer patients undergoing bronchoplasty: findings from a retrospective cohort study in a large-volume center in China.Journal of thoracic disease · 2026Article
- Article
- Machine Learning Prediction of Prolonged Length of Stay in Older Patients with Lung Cancer: A Multicenter Study Using XGBoost with SHAP Interpretation.Cancer management and research · 2026Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLung surgery remains the cornerstone of curative treatment for lung cancer, providing the best long-term survival in resectable disease. Advances in operative techniques and perioperative management have made it a safe and effective procedure, even in elderly or comorbid patients. Nevertheless, postoperative pulmonary complications (PPCs) remain a major source of morbidity and mortality. While surgical magnitude and functional capacity are recognised determinants, the contribution of comorbidities has not been adequately quantified. This study evaluated the relationship between cardiac, pulmonary, and metabolic comorbidities and postoperative complications in patients undergoing lung-cancer resection.
methodsA retrospective cohort of 328 patients who underwent lung-cancer surgery during 2018–2024 was analysed. Variables included age, sex, BMI, pulmonary-function tests, and comorbidities {chronic obstructive pulmonary disease (COPD), coronary artery disease (CAD), dyslipidemia, hypertension, diabetes, smoking, chronic renal disease}. Logistic-regression models estimated odds ratios and adjusted ORs for predictors of any PPC.
resultsPPCs occurred in 97/328 patients (29.6%). Univariate analysis identified COPD, CAD, and dyslipidemia as significant predictors (p < 0.05). In multivariable analysis adjusted for age, sex, BMI, and FEV1/FVC, COPD (aOR 2.8, 95% CI 1.4–5.4), CAD (aOR 2.3, 95% CI 1.1–4.9), and dyslipidemia (aOR 2.6, 95% CI 1.1–6.1) remained independent predictors of complications. A comorbidity-burden score showed a 40% increase in odds of PPCs per additional comorbidity (aOR 1.4 per point, p = 0.02).
conclusionsLung cancer surgery is a safe procedure however it has to be performed in properly selected patients due to risk of complications. Cardiac, pulmonary, and metabolic comorbidities—particularly COPD, coronary artery disease, and dyslipidemia—are independent predictors of postoperative pulmonary complications. Comprehensive preoperative evaluation and optimisation of these comorbidities are essential to minimise perioperative risk and improve outcomes after lung-cancer resection.
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