Evidence map›Paper›PMID 42035070›Full record

ArticleJournal of nanobiotechnology2026

Porphyrin oriented bimetallic sonodynamic MOF for enhanced ferroptosis and cGAS-STING pathway mediated antitumor immunotherapy.

Huan-Hui Wang, Long-Yi Nan, Yan Zheng, Jianpeng Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Huan-Hui WangCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji, 133002, PR China.
Long-Yi NanCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji, 133002, PR China.
Yan ZhengCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji, 133002, PR China. zhengyan_0308@163.com.
Jianpeng GuoCollege of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji, 133002, PR China. gjp807@ybu.edu.cn.

Funding

the National Natural Science Foundation of China 82460701the Natural Science Foundation of Jilin Province, China YDZJ202501ZYTS188
6 · The paper itself

Abstract

Sonodynamic therapy (SDT) offers deep tissue penetration and noninvasive tumor treatment, yet its efficacy remains limited by inadequate reactive oxygen species (ROS) generation and an immunosuppressive tumor microenvironment (TME). In this work, we developed a porphyrin-based bimetallic nanoplatform by integrating Fe and Mn centers within a structurally ordered metal-organic framework (MOF), followed by surface modification with the tumor-homing peptide CRGDK to achieve active targeting. The rationally engineered Mn-Fe(TCPP) MOF exhibits a spatially confined configuration that minimizes π-π aggregation of porphyrins enhancing ROS production under ultrasound (US). Meanwhile, Fe

Indexed as

cGAS-STING Signaling PathwayFerroptosisImmunotherapyMetal-Organic FrameworksNeoplasmsNucleotidyltransferasesPorphyrinsUltrasonic TherapyAnimalsAntineoplastic AgentsCell Line, TumorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseGlutathioneHumansIronManganeseAntineoplastic AgentsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseGlutathioneIronManganeseMembrane ProteinsMetal-Organic FrameworksNucleotidyltransferasesPorphyrinsReactive Oxygen SpeciesSTING ProteincGAS–STING pathwayFerroptosisImmunogenic cell deathPorphyrinic bimetallic MOFSonodynamic therapy

Identifiers

PMID42035070
PMCPMC13255352

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.