Evidence map›Paper›PMID 42034994›Full record

ArticleBMC infectious diseases2026

Metagenomic and genomic characterization of extrapulmonary Mycobacterium abscessus infections: a comparative cohort study.

Yu Chen, Rong Bao, Wengting Jin, Xiaoyu Yin, Le Qin, Jue Pan, Yumeng Yao, Jiajing Shen, Tingting Fang, Yuyan Ma and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Yu Chen *Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Rong Bao *Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Wengting JinDepartment of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaoyu YinDepartment of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Le QinDepartment of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Jue PanDepartment of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Yumeng YaoDepartment of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiajing ShenDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Tingting FangDepartment of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Yuyan MaDepartment of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Chunmei ZhouDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Qing Miao *Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. miao.qing@zs-hospital.sh.cn.
Bijie Hu *Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. hu.bijie@zs-hospital.sh.cn.

Funding

Shanghai Shen Kang Hospital Development Center SHDC22024315
6 · The paper itself

Abstract

introductionThe incidence of Mycobacterium abscessus complex (MABC) infections is rising, becoming a major pathogen of nontuberculous mycobacteria responsible for pulmonary disease (PD) and extrapulmonary disease (ED). However, studies on the clinical characteristics of MABC-ED remain limited.

methodsA 7-year retrospective analysis was conducted on MABC-ED cases at Zhongshan Hospital in Shanghai, China. We analyzed predisposing factors, clinical features, metagenomic sequencing (MS) results, drug susceptibility testing (DST), and genomic characteristics of MABC-ED patients, comparing the data with those of PD cases.

resultsAmong 17 MABC-ED patients, 15 had predisposing risk factors and underlying conditions, with 2 of 3 patients with rheumatic disease showing poor prognosis. The diagnostic performance of metagenomic sequencing for MABC-ED was comparable to that for MABC-PD. However, MABC-ED samples exhibited distinct microbiome features and a more diverse mycobacterial community structure compared to PD. Resistance rates among extrapulmonary MABC isolates were observed as follows: 0% (amikacin), 20% (macrolides), 30% (linezolid), and 40% (cefoxitin). One case showed paradoxical results between erm (41) T28 sequevar and susceptibility phenotype. Genomic analysis revealed no specific dominant circulating clones (DCC) for MABC-ED isolates.

conclusionMABC-ED patients commonly present with risk factors and underlying diseases. Metagenomic sequencing diagnosis of MABC-ED poses challenges, and DST and whole genome sequencing data indicate diversity among MABC-ED isolates. Our study provides detailed data on MABC-ED, contributing to a better understanding of its disease characteristics.

Indexed as

MetagenomicsMycobacterium abscessusMycobacterium Infections, NontuberculousAgedAnti-Bacterial AgentsChinaDrug Resistance, BacterialFemaleGenome, BacterialHumansMaleMicrobial Sensitivity TestsMiddle AgedRetrospective StudiesRisk FactorsAnti-Bacterial AgentsExtra-pulmonary infectionsMetagenomic sequencingMycobacterium abscessus complexWhole-genome sequencing

Identifiers

PMID42034994
PMCPMC13255413

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