ArticleJournal of fluorescence2026
Zirconium-Triggered Aggregation-Induced Emission of Copper Nanoclusters for the Sensitive Fluorescent Detection of Acid Phosphatase.
Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acid phosphatase (ACP) serves as a vital clinical biomarker for the diagnosis of various pathological conditions. Herein, a sensitive fluorescent platform was developed for ACP detection, leveraging biocompatible Zr4+ ions as a molecular trigger for aggregation-induced emission (AIE) of 4,6-diamino-2-mercaptopyrimidine-capped copper nanoclusters (DAMP-CuNCs). The coordination between Zr4+ and N atoms of the DAMP ligands facilitated the self-assembly of CuNCs into micro-scale aggregates, thereby significantly amplifying the fluorescence intensity. In the presence of ACP, the enzymatic hydrolysis of the substrate L-ascorbic acid-2-phosphate (AAP) produced inorganic phosphate groups (PO43−). Owing to the superior affinity of Zr4+ toward phosphate, the pre-formed aggregates were effectively dissociated through a competitive coordination mechanism, leading to a significant “Turn-Off” fluorescence state. Under optimized conditions, the assay exhibited a wide linear range from 0.1 to 20 U/L for ACP analysis, with a low detection limit (LOD) of 0.04 U/L. Furthermore, the assay was successfully applied to the determination of ACP in human serum samples, demonstrating its great potential for clinical diagnostics and biological research.
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