Evidence map›Paper›PMID 42034767›Full record

ArticleScientific reports2026

Association between periodontal status and salivary interleukin-6 levels in normal-weight and obese individuals with and without prediabetes.

Marwa Y Shaheen, Amani M Basudan, Rakan Saifuddin Shaheen, Fatemah M AlAhmari, Nouf Alshibani, Lamees Alssum, Fatima Alzahraa Yassin Shaheen, Mohammed Rami Shaath, Reem Al-Kattan

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marwa Y ShaheenDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia. mashaheen@ksu.edu.sa.
Amani M BasudanDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Rakan Saifuddin ShaheenPeriodontics Division, Department of Preventive Dentistry, College of Medicine and Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia.
Fatemah M AlAhmariDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Nouf AlshibaniDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Lamees AlssumDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Fatima Alzahraa Yassin ShaheenConsultant, Emergency department, SFHPR security force hospital program, Riyadh, Saudi Arabia.
Mohammed Rami ShaathDepartment of Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Reem Al-KattanDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective was to investigate the association between periodontal status and whole salivary interleukin-6 (IL-6) concentrations in normal-weight and obese individuals with and without prediabetes. Normoglycemic and prediabetic adults with obesity and systemically healthy individuals (controls) were encompassed. Participants were alienated into four-groups: Group-1: individuals with prediabetes alone, Group-2: individuals with obesity alone, Group-3: prediabetic individuals with obesity, and Group-4: systemically healthy individuals. Patient demographics were recorded. Clinical evaluations comprised measurements of probing depth (PD), clinical attachment loss (CAL), marginal bone loss (MBL), gingival index (GI), and plaque index (PI). Hemoglobin A1c was recorded and whole salivary IL-6 levels were measured. Associations between IL-6 levels, demographic variables, and periodontal parameters were examined using linear regression analysis. Intergroup differences were evaluated, and a significance threshold of P < 5% was applied. One-hundred-and-four individuals were assessed for eligibility. Fifteen individuals were excluded. In total, 89 individuals were included. The PI (P < 0.01),GI (P < 0.01),CAL (P < 0.01),PD (P < 0.01), MBL (P < 0.01),MT (P < 0.01) and IL-6 levels (P < 0.01) were significantly higher among individuals in Group 3 than groups 1, 2 and 4. There was a significant correlation between PD and IL-6 levels in group-3 (P < 0.001). Prediabetes in the presence of obesity is associated with an increased burden of periodontal inflammation; however, this relationship appears to be modulated by oral hygiene practices rather than solely by systemic status.

Indexed as

Interleukin-6ObesityPrediabetic StateSalivaAdultFemaleGlycated HemoglobinHumansMaleMiddle AgedPeriodontal IndexGlycated HemoglobinIL6 protein, humanInterleukin-6Alveolar bone lossClinical attachment lossInterleukin-6ObesityPrediabetesSaliva

Identifiers

PMID42034767
PMCPMC13284407

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