Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Examining recruitment differences by race, ethnicity, and age to a decentralized trial of an internet-delivered intervention for sexual health after breast cancer: the WF-2202 SHINE trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06216574 (Optimizing Psychosocial Intervention for Breast Cancer-Related Sexual Morbidity), which is not on this map. Not yet cited in PubMed.
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Optimizing Psychosocial Intervention for Breast Cancer-Related Sexual Morbidity:The Sexual Health and Intimacy Education (SHINE) Trial
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14 authors.
Funding
Abstract
purposeAchieving demographically representative samples remains a challenge in oncology trials but is essential for generalizable findings. We describe recruitment and enrollment to a decentralized trial for an online sexual health intervention for breast cancer survivors, evaluating differences by race, ethnicity, and age.
methodsPartnered breast cancer survivors with sexual concerns were recruited to the Sexual Health and Intimacy Enhancement (SHINE) trial (WF-2202, NCT06216574) via the Wake Forest NCI Community Oncology Research Program (NCORP) Research Base. Sites identified potentially eligible survivors; recorded their race, ethnicity, and age; and sent them online eligibility screeners. Eligible, consenting survivors were enrolled.
resultsScreener completion (78.3%, n = 557/711), eligibility (66.6%, n = 371/557), and enrollment (91.9%, n = 341/371) rates were high, but there were discrepancies by race and age. Eligible White survivors were more likely to enroll than eligible survivors from other races (94.4% vs. 87.0%, p = .03). Survivors who completed screeners were younger on average than those who did not (age M = 52.6 vs. 54.5, p = .05); eligible survivors were also younger on average than ineligible survivors (age M = 51.9 vs. 54.6, p = .004). There were no other differences in screener completion, eligibility, or enrollment by race, ethnicity, or age (ps > .06).
conclusionsDifferences in screener completion and enrollment by age and race suggest younger, White breast cancer survivors may have had the greatest interest in this trial of an online sexual health intervention. Overall, however, screener completion, eligibility, and enrollment rates were substantially higher for this trial than past clinical trials in oncology, demonstrating the benefits of decentralized trials through the NCORP network. CLINICAL
trial registrationClinicalTrials.gov NCT06216574 (Registered: January 22, 2024).
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