Evidence map›Paper›PMID 42034385›Full record

Trial reportThe Journal of physiology2026

Psychological stress catalyses free radical-mediated activation of coagulation in humans.

Lewis Fall, Benjamin S Stacey, Elsie Swain, Ebony Samuel, Meghan Robinson, Danny W Walmsley, Christopher J Marley, Thomas S Owens, Adnan Haq, Leon G Yandle and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lewis FallNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.ORCID https://orcid.org/0000-0002-1515-0672
Benjamin S StaceyNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.ORCID https://orcid.org/0000-0003-1005-7038
Elsie SwainNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.
Ebony SamuelNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.
Meghan RobinsonNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.
Danny W WalmsleyNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.
Christopher J MarleyNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.
Thomas S OwensNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.ORCID https://orcid.org/0000-0003-0097-0616
Adnan HaqNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.
Leon G YandleNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.
Kevin CoxNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.
Damian M BaileyNeurovascular Research Laboratory, University of South Wales, Pontypridd, UK.ORCID https://orcid.org/0000-0003-0498-7095

Funding

Royal Society WM170007
6 · The paper itself

Abstract

Psychological stress is a recognised, yet mechanistically unresolved, risk factor for cardiovascular disease (CVD) partly through its association with a hypercoagulable state. Free radical-mediated oxidative stress has been proposed as a key upstream driver of this haemostatic imbalance. In this randomised cross-over study we investigated whether acute psychological stress promotes systemic radical formation and prothrombotic alterations in clot microstructure in eight healthy males. The Trier Social Stress Test was used to induce psychological stress. Antecubital venous blood was collected to measure the ascorbate free radical (A

Indexed as

Blood CoagulationStress, PsychologicalAdolescentCross-Over StudiesFree RadicalsHumansMaleOxidative StressYoung AdultFree Radicalshaemostasisoxidative stressstress

Identifiers

PMID42034385
PMCPMC13267672

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.