ReviewThe Journal of allergy and clinical immunology2026
Update on environmental determinants of allergic diseases.
Review in The Journal of allergy and clinical immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
This review article summarizes key advances from October 2022 to December 2025 on the link between environmental exposures and allergic diseases, with an emphasis on early-life exposures and mechanistic insights relevant to disease prevention and therapy. Allergic diseases have genetic and environmental origins. As to the latter, predisposition to allergy is thought to arise as a result of increased exposure to harmful environmental factors that act as immune adjuvants for allergens, and reduced exposure to beneficial factors that induce allergen tolerance. Harmful factors include air pollutants (eg, road traffic-related particulate matter and gases, cigarette smoke, fire smoke), and various man-made chemicals and particles. Beneficial exposures include commensal microorganisms and nonmicrobial factors present in the farming environment. Allergic diseases frequently start in early childhood. Therefore, many recently published reports focus on environmental exposures occurring prenatally or during the first few months or years after birth-that is, time windows before allergic disease manifestation. This review article summarizes and comments on recent work on prenatal, childhood, adult, protective, and harmful exposures, highlighting relevant human cohort studies as well as mechanistic work in mouse models and in vitro culture systems. Studies published in the past 3 years describe novel biomarkers of environmental exposures, elucidate novel mechanisms by which exposures shape allergic diseases, and highlight novel targets for therapeutic intervention, setting a foundation for new approaches for early detection of allergic predisposition, allergy treatment, and prevention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.