Evidence map›Paper›PMID 42034056›Full record

ArticleNeuron2026

Macrophage-mediated refinement of the dural lymphatic regulates social behavior.

Gabriel A Tavares, Liam O'Reilly, Natalie M Frederick, David A Shapiro, Ashleigh Vicchiarelli, Megan Sullivan, Nathan Jiang, Maximillian Mattes, Coby Goelz, Nnadozie Uchegbu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gabriel A TavaresDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Liam O'ReillyDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Natalie M FrederickDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
David A ShapiroDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Ashleigh VicchiarelliDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Neurosciences, School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA.
Megan SullivanDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Nathan JiangDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Maximillian MattesDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Coby GoelzDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Nnadozie UchegbuDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Haley BrownDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Joseph LuberaDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Laura WolfeDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Brendan T BoylanDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Cornelia BergmannDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Neurosciences, School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA.
Tara M DeSilvaDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Antoine LouveauDepartment of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Neurosciences, School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA. Electronic address: louveaa@ccf.org.

Funding

Medical Scientist Training Program at Case Western Reserve UniversityT32GM152319 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Heather Broihier, Alex Yee-Chen Huang · 2024 to 2026
$5.1M
Lymphatic dysfunction in neurodevelopmental disorders and associated behaviorsR01MH133584 · NIMH · CLEVELAND CLINIC LERNER COM-CWRU · PI Antoine Louveau · 2025 to 2026
$644k
NIGMS NIH HHS T32 GM152319NIMH NIH HHS R01 MH133584
6 · The paper itself

Abstract

The meningeal lymphatic vasculature has recently emerged as a central player in the regulation of brain function under normal and pathological conditions. The dorsal meningeal/dural lymphatics expand uniquely postnatally during a critical window for brain maturation. The mechanisms driving their development and function, however, remain poorly understood. Here, we demonstrate that the developing dorsal meningeal lymphatic vasculature, contrary to peripheral counterparts, undergoes defined refinement orchestrated by cell death and phagocytosis by meningeal macrophages. Alteration of this refinement is observed in the BTBR mouse model of autism spectrum disorder (ASD) and appears to regulate ASD-like social behavior. Together, our results demonstrate a new pathway regulating meningeal lymphatic development that may contribute to brain maturation and function.

Indexed as

Autism Spectrum DisorderDura MaterLymphatic VesselsMacrophagesMeningesSocial BehaviorAnimalsBrainDisease Models, AnimalMaleMiceMice, Inbred C57BLPhagocytosisbehaviormeningeal lymphaticneurodevelopmentneuroimmunologyphagocytosis

Identifiers

PMID42034056
PMCPMC13120720

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.