Evidence map›Paper›PMID 42033918›Full record

ArticlePoultry science2026

Distinct infectivity, pathogenicity, and adaptive evolution of clade 2.3.4.4 H5N2 avian influenza viruses in chickens in Taiwan.

Li-Hsuan Chen, Yu-Ju Lin, Yu-Pin Liu, Wan-Chen Li, Yang-Chang Tu, Shu-Chia Hu, Wei-Cheng Hsu, Yen-Wen Chen, Fan Lee, Shan-Chia Ou and 2 more

Abstract read
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Li-Hsuan ChenVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan; Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.
Yu-Ju LinVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan.
Yu-Pin LiuVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan.
Wan-Chen LiVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan.
Yang-Chang TuVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan.
Shu-Chia HuVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan.
Wei-Cheng HsuVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan.
Yen-Wen ChenVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan.
Fan LeeVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan.
Shan-Chia OuGraduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.
Ming-Chung DengVeterinary Research Institute, Ministry of Agriculture, New Taipei City, Taiwan.
Wei-Li HsuGraduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan; The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan; Doctoral Program in Microbial Genomics, National Chung Hsing University and Academia Sinica, Taichung, Taiwan. Electronic address: wlhsu@dragon.nchu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High pathogenicity avian influenza virus (HPAIV) drives fulminant poultry epizootics with high mortality and significant production losses. In Taiwan, HPAIV clade 2.3.4.4c H5N2 has circulated since 2015 across different farms, providing an opportunity to assess strain-specific virulence over time. Four representative strains were examined: the index strain GS-2015 (January 2015) and three subsequent isolates-CK-2015 (December 2015), CK-2017 (2017), and CK-2018 (2018). Virulence was evaluated in the chicken model alongside genomic characterization. Overall, strains isolated after the index case exhibited higher mortality rates, shorter mean death times (MDTs), and lower minimal lethal doses compared with GS-2015. Marked variation in the 50 % bird lethal dose (BLD

Indexed as

ChickensInfluenza A Virus, H5N2 SubtypeInfluenza in BirdsPoultry DiseasesAnimalsPhylogenyTaiwanVirulenceAdaptationClade 2.3.4.4cH5N2 subtypeHigh pathogenicity avian influenzaPathogenicity

Identifiers

PMID42033918
PMCPMC13126490

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.