ReviewCurrent opinion in cell biology2026
Structural mechanisms of cargo adaptors in membrane trafficking.
Review in Current opinion in cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Eukaryotic cells have evolved multiple intracellular trafficking pathways to control the precise sub-cellular localization of proteins and lipids. Key to this process are cargo adaptors, which cooperate with the coat machinery to package and deliver transmembrane cargo with directional specificity. Recent insights indicate how cargo adaptors act as active recognition and regulatory modules to integrate allosteric cues that couple cargo recognition with coat recruitment, coat polymerization, and membrane deformation. In this review, we discuss recent molecular insights into the adaptor protein (AP) family and endosomal sorting nexin (SNX) proteins that recognize cargoes throughout cells. We further highlight how the designation of coat versus adaptor is challenging in systems where these functions have merged into a single complex or cannot be easily ascribed to one versus the other.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.