Evidence map›Paper›PMID 42033848›Full record

ArticleRedox biology2026

Extracellular vesicles derived by hypoxic preconditioned EPCs attenuated atherosclerosis by suppressing ferroptosis via regulating arginine metabolism.

Xing Luo, Xinxin Zhu, Yuwu Chen, Yiyuan Guo, Biyi Xu, Junke Mou, Mengyang Wang, Qishuo Gu, Qianhui Sun, Ying Lv and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xing LuoDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Xinxin ZhuDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Yuwu ChenDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Yiyuan GuoDepartment of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Biyi XuDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Junke MouDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Mengyang WangDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Qishuo GuDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Qianhui SunDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Ying LvDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Xingtao HuangDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Ming ZengDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Boling YiDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Xiaolin LiuDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Xiaoxuan BaiDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Cheng FangDepartment of Experimental Animal Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Ji LiDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Bo YuDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.
Haibo JiaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China. Electronic address: jhb101180@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial progenitor cells (EPCs) derived extracellular vesicles (EVs) are involved in maintaining vascular homeostasis, while effects of hypoxic preconditioned EPCs-derived EVs (Hy-EVs) on atherosclerosis (AS) remain unclear. Hy-EVs and normal oxygen EVs (N-EVs) were pretreated for ApoE

Indexed as

ArginineAtherosclerosisEndothelial Progenitor CellsExtracellular VesiclesFerroptosisAnimalsArgininosuccinate SynthaseDisease Models, AnimalMacrophagesMiceNF-E2-Related Factor 2Oxidative StressArginineArgininosuccinate SynthaseNfe2l2 protein, mouseNF-E2-Related Factor 2Arginine metabolismAtherosclerosisFerroptosisGCN2

Identifiers

PMID42033848
PMCPMC13126339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.