Observational studyRheumatology (Oxford, England)2026
Pericoronary adipose tissue as a biomarker of coronary atherosclerosis and cardiovascular risk in rheumatoid arthritis.
Observational study in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Complement Activation by Post-Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity.Immunological reviews · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesPericoronary adipose tissue attenuation (PCATa) on computed tomography angiography reflects coronary artery inflammation and associated with cardiovascular risk beyond atherosclerosis in general patients. We aimed to evaluate the relationships between PCATa and coronary atherosclerosis burden, progression and cardiovascular risk in rheumatoid arthritis (RA).
methodsA total of 150 patients in a single-centre observational cohort underwent screening and surveillance coronary imaging 6.9 ±0.3 years later. PCATa around left anterior descending (LAD), left circumflex (LCx) and right coronary artery (RCA) were measured. Numbers of atherosclerotic segments (disease extent), plaque composition (noncalcified, low-density, mixed or calcified) and absolute volumes (mm3, plaque burden) were computed.
resultsMean (adjusted incidence rate ratio 1.21 [95% confidence interval 1.02-1.27]), LCx (1.20 [1.00-1.43]) and RCA-PCATa (1.22 [1.02-1.46] per standard deviation (SD) increase) associated with total plaque numbers and variably with plaque subtype extent and burden at baseline. Mean and artery-specific PCATa exhibited diverse associations with total, noncalcified, low-density and calcified plaque progression. Using artery-specific PCATa thresholds, mean (adjusted hazards ratio 0.10 [95% CI 0.02-0.56]), LCx (0.11 [95% CI 0.03-0.43]) and RCA-PCATa (0.15 [0.04-0.53] per SD increase) were linked to cardiovascular risk. RCA-PCATa threshold in particular increased risk estimate accuracy (ΔAUC = 0.066 [bias-corrected 95% CI 0.024-0.126], P = 0.005).
conclusionMean and artery-specific PCATa associated with the extent, burden and composition of coronary plaque and its progression in RA. Mean, LCx and RCA-PCATa were linked to cardiovascular events, and RCA-PCATa specifically optimized risk estimates beyond atherosclerosis, highlighting its potential utility as a predictive biomarker.
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