ArticleCardiovascular research2026
Age-dependent dysregulation of collagen metabolism in primary cardiac fibroblasts in vitro.
Article in Cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionFibroblast-driven collagen remodelling is a key process in cardiac ageing and fibrosis, yet how age and sex alter fibroblast collagen handling remains poorly characterized. This proof-of-concept study aimed to address this knowledge gap, as currently the effects of age and sex on cardiac fibroblast (cFb) collagen metabolism remain incompletely understood. METHODS AND
resultscFbs were isolated from young (4-week) and aged (18-month) Sprague-Dawley rats and cultured in vitro. Unhydroxylated (immature) and hydroxylated (mature) collagen synthesis was estimated using cis- and trans-4-[18F]fluoro-L-proline PET radiotracers as a proxy measure of collagen synthesis. Insoluble and soluble collagen deposition was assessed using colorimetric assays. No sex differences were observed in hydroxylated and hydroxylated collagen synthesis. Ageing resulted in increased hydroxylated and unhydroxylated collagen synthesis in males. Insoluble collagen deposition was higher in young males than females and decreased with ageing.
conclusionCollagen metabolism in cFbs is influenced by age, with ageing uncoupling synthesis and deposition. These findings provide preliminary mechanistic insight and intrinsic fibroblast-level differences that may underlie age- and sex-dependent cardiac remodelling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.