ArticlePlant cell reports2026
DcMYB5 transcription factor regulates the biosynthesis of diosgenin by directly repressing CYP90B gene expression in Dioscorea composita.
Article in Plant cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
key messageDcMYB5 regulates diosgenin biosynthesis in Dioscorea composita by binding to the DcCYP90B promoter and repressing its transcription. Diosgenin is an important bioactive metabolite in Dioscorea with significant pharmaceutical and ecological value. However, the transcriptional regulatory mechanisms of its biosynthesis remain poorly understood. Here, we identified and characterized an SG5 subgroup R2R3-MYB transcription factor (TF) from Dioscorea composita, designated DcMYB5. Sequence and phylogenetic analyses identified DcMYB5 as a MYB5-type SG5 MYB TF with typical R2R3 conserved domains but lacking the C3 motif at the C-terminus. Functional gene silencing and overexpression experiments validated that DcMYB5 modulates the biosynthesis of diosgenin and its derivatives, along with tuber growth. Dual-luciferase and yeast one-hybrid assays further indicated that DcMYB5 binds to the DcCYP90B promoter and represses its transcription, thereby regulating diosgenin accumulation. Overall, this study provides new insights into how R2R3-MYB TFs coordinate steroidal metabolism with growth in D. composita and delivers an actionable molecular target for agricultural biotechnology to enhance high-value steroidal saponin production.
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