Evidence map›Paper›PMID 42033636›Full record

ArticleMarine biotechnology (New York, N.Y.)2026

Identifying Target Genes for Engineered Genetic Incompatibility in Fish.

Leland Feist, Samuel E Erickson, Nicholas Jacob, Isabel Ameli, Carolyn Malecha, Julie Badger, Michael J Smanski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leland FeistBiotechnology Institute, University of Minnesota, Saint Paul, MN, 55108, USA.
Samuel E EricksonBiotechnology Institute, University of Minnesota, Saint Paul, MN, 55108, USA.
Nicholas JacobBiotechnology Institute, University of Minnesota, Saint Paul, MN, 55108, USA.
Isabel AmeliBiotechnology Institute, University of Minnesota, Saint Paul, MN, 55108, USA.
Carolyn MalechaConservation Science Graduate Program, Saint Paul, MN, 55108, USA.
Julie BadgerBiotechnology Institute, University of Minnesota, Saint Paul, MN, 55108, USA.
Michael J SmanskiBiotechnology Institute, University of Minnesota, Saint Paul, MN, 55108, USA. smanski@umn.edu.

Funding

An Interdisciplinary Training Program to Transform Graduate Education In Genetics and GenomicsT32GM140936 · NIGMS · UNIVERSITY OF MINNESOTA · PI ALBERT, FRANK WOLFGANG, GREENSTEIN, DAVID IRWIN · 2021 to 2025
$851k
NIGMS NIH HHS T32 GM140936NIH HHS T32GM140936
6 · The paper itself

Abstract

Genetic biocontrol approaches promise to complement existing physical and chemical methods as part of integrated pest management (IPM) strategies for the control of aquatic invasive species (AIS). Engineered Genetic Incompatibility (EGI) is a strategy for producing organisms that are reproductively isolated from wild conspecifics and could be used as non-persistent genetic biocontrol agents. Previously successfully demonstrated in yeast and insects, here we report early-stage research and development results towards translating this approach from insects into fish. Using Danio rerio (zebrafish) as a model system, we report the identification of target genes and sequence-programmable transcriptional activators (PTAs) that are suitable for EGI development in fish and evaluate their performance in vivo, in a model organism. We also describe several challenges faced when integrating the component parts into a complete system capable of displaying complete genetic incompatibility with wild-type conspecifics. Lastly, we discuss the steps needed to translate EGI from a model fish species to a target invasive species such as common carp (Cyprinus carpio).

Indexed as

CarpsGenetic EngineeringPest Control, BiologicalZebrafishAnimalsAnimals, Genetically ModifiedIntroduced SpeciesCommon carpEngineered genetic incompatibilityNon-persistent genetic biocontrolZebrafish

Identifiers

PMID42033636
PMCPMC13110222

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.