Evidence map›Paper›PMID 42033586›Full record

ReviewUnited European gastroenterology journal2026

Upcoming Treatments in Celiac Disease: From Luminal Enzymes to Oral Immune Tolerance.

Juha Taavela, Luca Elli, Gerd Bouma, Jason A Tye-Din, Detlef Schuppan, Knut E A Lundin, Michael Schumann

Abstract readReview
In one paragraph

Review in United European gastroenterology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juha TaavelaFaculty of Medicine and Health Technology, Celiac Disease Research Center, Tampere University, Tampere, Finland.
Luca ElliCenter for Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Gerd BoumaDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Jason A Tye-DinImmunology Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0001-7687-9654
Detlef SchuppanInstitute of Translational Immunology and Coeliac Centre, Johannes Gutenberg University Mainz, Mainz, Germany.
Knut E A LundinNorwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Michael SchumannDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease (CeD) is a chronic autoimmune enteropathy triggered by dietary gluten in genetically predisposed individuals. Currently, a gluten-free diet (GFD) is the only available treatment, being effective in improving mucosal health and symptoms. However, a considerable percentage of celiacs continue to exhibit residual mucosal damage and symptoms. In addition, dietary lapses, and social and nutritional problems pose difficulties with the GFD. Hence, there is an unmet need for new treatments in CeD, driving the development of pharmacologic interventions, with several new drugs in various stages of clinical development. These drugs target distinct steps in the immune pathology of CeD and are intended for patients who continue to experience symptoms despite trying to follow a GFD. Also, the treatment should heal the defective small intestinal mucosa, which is believed to be linked to the risk of long-term complications. This review summarizes emerging CeD therapies, covering trial progress, mechanisms, and potential clinical applications.

Indexed as

Celiac DiseaseImmune ToleranceAdministration, OralAnimalsDiet, Gluten-FreeGlutensGTP-Binding ProteinsHumansIntestinal MucosaTransglutaminasesGlutensGTP-Binding ProteinsTransglutaminasesceliac diseaseduodenumgluten‐free dietoral tolerancesmall‐boweltransglutaminase

Identifiers

PMID42033586
PMCPMC13109976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.