ReviewDiscover oncology2026
Skeletal muscle as an endocrine and paracrine organ in breast cancer biology: a narrative review.
Review in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon muscle contraction during exercise and resistance training, skeletal muscle releases an array of bioactive molecules called myokines, allowing it to function as a dynamic endocrine organ. Myokines promote systemic and local effects, influencing metabolism and organ function. These myokines may also promote anticancer activity, particularly in breast cancer, and especially in ER/PR-positive, HER2-negative disease. Myokines may influence breast cancer tumor growth, progression, and treatment outcomes. Exercise oncology offers a unique means of optimizing the endocrine and paracrine actions of skeletal muscle-derived myokines within the clinical management of breast cancer. Therefore, the aim of this review is to integrate mechanistic, preclinical, and clinical evidence linking exercise-induced myokines to breast cancer biology, identify breast cancer-specific regulators of myokine signaling, and outline practical implications for exercise oncology prescription and future clinical trial design.
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