ArticleThe Journal of organic chemistry2026
Synthesis of Bufadienolide Natural Products and Analogs via Singlet Oxygen Oxidation and Late-Stage Modification.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Synthesis of Bufadienolide Natural Products and Analogs via Singlet Oxygen Oxidation and Late-Stage Modification.The Journal of organic chemistry · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
In this work, we describe the synthesis of three new bufadienolide natural products cinobufotalin, bufotalin, and 5β-hydroxybufotalin and four new analogs of resibufogenin, bufalin, telocinobufagin, and marinobufogenin. This was achieved by developing a unified pathway that features installation of the characteristic α-pyrone ring onto steroid scaffolds with or without C5 oxygenation, and introduction of D-ring oxidation through a photochemical singlet oxygen [4 + 2] cycloaddition/endoperoxide rearrangement to furnish 14β,16β-
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Registered trials
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