ArticleMolecular oncology2026
DNA methylation and expression of MAPRE3 affect overall survival of early-stage non-small cell lung cancer patients.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland and 5 more
Abstract read
In one paragraphArticle in Molecular oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
Chao ChenDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Jiangsu, China.
Jiancheng ChengDepartment of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Jiangsu, China.
Xiaoyuan ZhengInformation Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Jiangsu, China.
Li SuDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Anna KarlssonDivision of Oncology, Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Sweden.
Maria PlanckDivision of Oncology, Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Sweden.
Åslaug HellandDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Norway.
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Xiaofei CaoDepartment of Anesthesiology and Perioperative Medicine, The First School of Clinical Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China.ORCID https://orcid.org/0000-0002-6676-4658 Funding
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6MThe Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2MMolecular and Genetic Analysis of Lung Cancer SurvivalR01CA092824 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 2002 to 2013
$5.9MNew Statistical Methods for Modelling Cancer OutcomesR01CA249096 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yi Li · 2021 to 2026
$2.5MNational Natural Science Foundation of China 82220108002 82273737NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA249096NCI NIH HHS U01 CA209414NIEHS NIH HHS P30 ES000002NIH HHS CA209414 CA249096 CA092824 ES000002Outstanding Young Teachers Training Program of Nanjing Medical UniversityPriority Academic Program Development of Jiangsu Higher Education Institutions
6 · The paper itselfAbstract
The MAPRE3 gene is aberrantly expressed in several cancers. We profiled DNA methylation in tumor tissues from early-stage non-small cell lung cancer (NSCLC) patients and assessed associations with overall survival (OS). Significant CpG probes were validated in The Cancer Genome Atlas (TCGA). The methylation level of cg12821679
Indexed as
Carcinoma, Non-Small-Cell LungDNA MethylationGene Expression Regulation, NeoplasticLung NeoplasmsMicrotubule-Associated ProteinsAgedCpG IslandsFemaleHumansMaleMiddle AgedNeoplasm StagingMicrotubule-Associated ProteinsDNA methylationMAPRE3non‐small cell lung canceroverall survivalsmoking cessation
Identifiers
PMID42033322
PMCPMC13398577
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