Evidence map›Paper›PMID 42033215›Full record

ReviewCancer biology & therapy2026

Advances in natural killer cell immunotherapy for hematologic malignancies.

Huijie Hu, Yan Xiong, Minxin Xia, Lixia Sheng

Abstract readReview
In one paragraph

Review in Cancer biology & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Huijie HuSchool of Medicine, Ningbo University, Ningbo, Zhejiang Province, China.ORCID 0009-0001-5204-7543
Yan XiongSchool of Medicine, Ningbo University, Ningbo, Zhejiang Province, China.
Minxin XiaSchool of Medicine, Ningbo University, Ningbo, Zhejiang Province, China.
Lixia ShengDepartment of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, China.ORCID 0000-0003-0631-7140

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells are a unique subset of cytotoxic lymphocytes within the innate immune system. They play a pivotal role in antiviral and antitumor immunity. NK cell-based adoptive immunotherapy has advanced rapidly in recent years. Innovative approaches, such as autologous/haploidentical NK cell infusion, chimeric antigen receptor NK cells, and NK cell engagers, have emerged, demonstrating promising potential in the treatment of various diseases. Currently, enhancement strategies for NK cell therapy primarily focus on two key aspects: improving expansion efficiency and persistence, with a positive effect on the therapy's potency and cytotoxic efficacy. The present review systematically introduces the functional mechanisms of NK cells and their specialized functional subsets. This review discusses the progress and optimization methods of NK cell therapy and provides an outlook on future research directions.

Indexed as

Hematologic NeoplasmsImmunotherapyImmunotherapy, AdoptiveKiller Cells, NaturalAnimalsHumanscell transfer therapyCellular therapyhematologic tumorsimmunotherapyNK cell

Identifiers

PMID42033215
PMCPMC13114117

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.