ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
Metabolic Health and Fitness Do Not Differ Substantially Between Overweight Adults With and Without α-Actinin-3 Deficiency.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The common ACTN3 R577X polymorphism leads to α-actinin-3 deficiency in ~20% of the human population and may be detrimental to their muscle power. However, the impact of ACTN3R577X on metabolic health and exercise capacity in the general population remains unclear. The objective of the current study was to compare metabolic health markers, musculoskeletal traits, and cardiorespiratory capacity between untrained overweight α-actinin-3-deficient (XX; 20 men and 19 women) and α-actinin-3 expressing (RR; 20 men and 21 women) individuals. The participants were aged 43 ± 7 years and had a BMI of 28.6 ± 3.2 kg·m
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