Evidence map›Paper›PMID 42033129›Full record

ArticleHead & neck2026

Establishment of Salivary Gland Tumors Arising in Salivary Gland-Specific EWSR1::ATF1 Transgenic Mice.

Yuri Hirai, Yoshitaka Utsumi, Daisuke Sano, Tatsu Kuwahara, Yoshihiro Aizawa, Takashi Hatano, Hisashi Hasumi, Yutaro Soejima, Tatsukata Kawagoe, Ryosuke Jikuya and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuri HiraiDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Yokohama, Japan.
Yoshitaka UtsumiDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Daisuke SanoDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Yokohama, Japan.
Tatsu KuwaharaDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Yokohama, Japan.
Yoshihiro AizawaDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Yokohama, Japan.
Takashi HatanoDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Yokohama, Japan.
Hisashi HasumiDepartment of Urology, School of Medicine, Yokohama City University, Yokohama, Japan.
Yutaro SoejimaRheumatic Diseases Center, Yokohama City University Medical Center, Yokohama, Japan.
Tatsukata KawagoeDepartment of Ophthalmology, Dokkyo Medical University, Tochigi, Japan.
Ryosuke JikuyaDepartment of Urology, School of Medicine, Yokohama City University, Yokohama, Japan.ORCID https://orcid.org/0000-0002-3446-6293
Nobuhisa MizukiDepartment of Ophthalmology and Visual Science, School of Medicine, Yokohama City University, Yokohama, Japan.
Satoshi FujiiDepartment of Molecular Pathology, School of Medicine, Yokohama City University, Yokohama, Japan.ORCID https://orcid.org/0000-0002-1789-9871
Toshitaka NagaoDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.ORCID https://orcid.org/0000-0003-2075-9738
Nobuhiko OridateDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Yokohama, Japan.ORCID https://orcid.org/0000-0002-6968-3028

Funding

Japan Society for the Promotion of Science 23K08989Japan Society for the Promotion of Science 24K02598Japan Society for the Promotion of Science 24K19775Japan Society for the Promotion of Science 25K12793Yokohama City University Hospital, Advanced Medical Treatment Support System 2019-112
6 · The paper itself

Abstract

backgroundSalivary gland carcinomas are uncommon malignancies with various histological subtypes harboring fusion genes. The EWSR1::ATF1 fusion gene, resulting from a translocation between chromosomes 12 and 22, is frequently observed in hyalinizing clear cell carcinoma (HCCC). However, the role of this fusion gene in HCCC oncogenesis remains unclear.

methodsWe generated EWSR1::ATF1 transgenic mice by introducing an EWSR1::ATF1 fusion gene with a breakpoint in HCCC. These mice were crossed with Lama parotid secretory protein (PSP)-Cre transgenic mice, expressing Cre recombinase in salivary glands, to produce salivary gland-specific EWSR1::ATF1 transgenic mice. Tumor samples were analyzed using Western blotting, histopathology, and RNA sequencing.

resultsWe generated salivary gland-specific EWSR1::ATF1 transgenic mice, and tumors developed in major salivary glands in three mice. These tumors exhibited more malignant characteristics than human HCCC.

conclusionsThese results suggest that salivary gland-specific expression of EWSR1::ATF1 plays an important role in malignant tumor formation in major salivary glands.

Indexed as

Activating Transcription Factor 1Oncogene Proteins, FusionRNA-Binding Protein EWSSalivary Gland NeoplasmsAnimalsBlotting, WesternFemaleHumansMiceMice, TransgenicActivating Transcription Factor 1Oncogene Proteins, FusionRNA-Binding Protein EWSCre recombinaseEWSR1::ATF1hyalinizing clear cell carcinomasalivary gland carcinomatransgenic mouse

Identifiers

PMID42033129
PMCPMC13595492

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.