Evidence map›Paper›PMID 42033099›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Endothelial NAD

Qing-Hua Luo, Fang Li, Li Yang, Han-Qing Pan, Wen-Ping Zhu, Ping Hu, Chu-Ming Tao, Min Yin, Si Zhang, Qiu-Ye Liao and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Qing-Hua LuoDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P. R. China.ORCID 0000-0003-2828-1118
Fang LiDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P. R. China.
Li YangJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.
Han-Qing PanDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P. R. China.
Wen-Ping ZhuJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.
Ping HuJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.
Chu-Ming TaoDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P. R. China.
Min YinDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P. R. China.
Si ZhangJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.
Qiu-Ye LiaoJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.
Zhi-Hao ChenJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.
Hong-Xin ShuJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.
Xin-Yi ZhuJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.
Teng-Feng YanJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.
Xu LiuDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P. R. China.
Jiang-Long TuDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P. R. China.
Xin-Gen ZhuJiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi, P. R. China.

Funding

China Postdoctoral Science Foundation 2023M741521Jiangxi Provincial Natural Science Foundation 20232BAB216047Jiangxi Provincial Natural Science Foundation 20242BAB20383Jiangxi Provincial Natural Science Foundation 20242BAB25478Jiangxi Provincial Natural Science Foundation 20242BAB26136National Natural Science Foundation of China 82260278National Natural Science Foundation of China 82501463
6 · The paper itself

Abstract

backgroundEndothelial dysfunction has emerged as early and pivotal event in Alzheimer's disease (AD), yet the molecular mechanisms linking vascular aging to neuroinflammation remain elusive.

methodsWe used APP/PS1 mice and amyloid beta (Aβ)-challenged brain endothelial cells (BECs) to understand the mechanisms of nicotinamide adenine dinucleotide (NAD

resultsNAD DISCUSSION: Aβ-driven NAD

Indexed as

Alzheimer DiseaseCellular SenescenceEndothelial CellsEndothelium, VascularNADADP-ribosyl Cyclase 1AnimalsBlood-Brain BarrierCerebrovascular CirculationCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialFemaleImmunity, InnateMaleMembrane GlycoproteinsMiceADP-ribosyl Cyclase 1Cd38 protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialMembrane GlycoproteinsNADSTING ProteinVdac1 protein, mouseVoltage-Dependent Anion Channel 1Alzheimer's diseasecGAS/STING pathwayendothelial senescenceNAD+ supplementationneuroinflammation

Identifiers

PMID42033099
PMCPMC13109647

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.