Evidence map›Paper›PMID 42033079›Full record

ArticleInternational journal of cancer2026

Lymphocyte Micronucleus Formation Is Driven by Inflammation-Induced Oxidative DNA Damage in Oesophageal Cancer Development.

Kathryn Munn, Rachel Lawrence, Hasan Haboubi, Hamsa Naser, Kate Hurlow, Ume-Kulsoom Shah, Lisa Williams, Sarah Gwynne, Owen Bodger, Jiri Zavadil and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kathryn MunnIn Vitro Toxicology Group, Swansea University Medical School, Swansea University, Swansea, UK.ORCID https://orcid.org/0009-0009-0960-6328
Rachel LawrenceCentre for Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, UK.
Hasan HaboubiDepartment of Gastroenterology, Llandough Hospital, Cardiff and Vale University Health Board, Cardiff, UK.
Hamsa NaserIn Vitro Toxicology Group, Swansea University Medical School, Swansea University, Swansea, UK.
Kate HurlowIn Vitro Toxicology Group, Swansea University Medical School, Swansea University, Swansea, UK.
Ume-Kulsoom ShahIn Vitro Toxicology Group, Swansea University Medical School, Swansea University, Swansea, UK.
Lisa WilliamsDepartment of Gastroenterology, Singleton Hospital, Swansea Bay University Health Board, Swansea, UK.
Sarah GwynneDepartment of Oncology, Singleton Hospital, Swansea Bay University Health Board, Swansea, UK.
Owen BodgerIn Vitro Toxicology Group, Swansea University Medical School, Swansea University, Swansea, UK.
Jiri ZavadilInternational Agency for Research on Cancer, Epigenomics and Mechanisms Branch, Lyon, France.
Francois VirardInternational Agency for Research on Cancer, Epigenomics and Mechanisms Branch, Lyon, France.
Shareen DoakIn Vitro Toxicology Group, Swansea University Medical School, Swansea University, Swansea, UK.
Laura E ThomasIn Vitro Toxicology Group, Swansea University Medical School, Swansea University, Swansea, UK.
Gareth JenkinsIn Vitro Toxicology Group, Swansea University Medical School, Swansea University, Swansea, UK.ORCID https://orcid.org/0000-0002-5437-8389

Funding

Cancer Research WalesSwansea University
6 · The paper itself

Abstract

We investigated mechanisms underlying circulating DNA damage across the gastro-oesophageal reflux disease (GORD), Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC) spectrum using the lymphocyte micronucleus (MN) assay. MN frequency (MN%) was quantified in lymphocytes from healthy volunteers (HVs), GORD, BO and OAC patients, alongside plasma biomarkers of inflammation and oxidative stress. Ex vivo challenge assays assessed lymphocyte responses to hydrogen peroxide (H

Indexed as

AdenocarcinomaDNA DamageEsophageal NeoplasmsInflammationLymphocytesMicronuclei, Chromosome-DefectiveOxidative StressAdultAgedBarrett EsophagusFemaleGastroesophageal RefluxHumansHydrogen PeroxideMaleMicronucleus TestsHydrogen PeroxideNF-kappa Bcirculating biomarkersDNA damagemicronucleusoesophageal adenocarcinomaoxidative stress

Identifiers

PMID42033079
PMCPMC13340993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.