Evidence map›Paper›PMID 42033075›Full record

ArticleAging cell2026

Aging-Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment.

Mary P Udumula, Anjaly Km, Faraz Rashid, Mohammad Nematullah, Harshit Singh, Tanya Bhardwaj, Miriana Hijaz, Shailendra Giri, Eduardo N Chini, Heather M Gibson and 1 more

Abstract read
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mary P UdumulaDivision of Gynecologic Oncology, Henry Ford Hospital, Detroit, Michigan, USA.
Anjaly KmDivision of Gynecologic Oncology, Henry Ford Hospital, Detroit, Michigan, USA.
Faraz RashidDepartment of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
Mohammad NematullahDepartment of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
Harshit SinghDivision of Gynecologic Oncology, Henry Ford Hospital, Detroit, Michigan, USA.
Tanya BhardwajDivision of Gynecologic Oncology, Henry Ford Hospital, Detroit, Michigan, USA.
Miriana HijazDivision of Gynecologic Oncology, Henry Ford Hospital, Detroit, Michigan, USA.
Shailendra GiriDepartment of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
Eduardo N ChiniDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0003-1555-4834
Heather M GibsonDepartment of Oncology, Wayne State School of Medicine, Detroit, Michigan, USA.
Ramandeep RattanDivision of Gynecologic Oncology, Henry Ford Hospital, Detroit, Michigan, USA.

Funding

Determining the mechanisms by which calorie restriction alters macrophage polarization to promote an anti-tumor environment in epithelial ovarian cancerR01CA249188 · NCI · HENRY FORD HEALTH SYSTEM · PI RATTAN, RAMANDEEP · 2020 to 2024
$1.7M
Henry Ford Health System A20091NCI NIH HHS R01 CA249188NCI NIH HHS R01CA249188
6 · The paper itself

Abstract

Epithelial ovarian cancer (EOC) incidence and mortality increase with age, driven in part by chronic inflammation, diminished T cell output, and heightened regulatory T cell (Treg) mediated immunosuppression. In aged EOC-bearing mice, we observed reduced survival, accompanied by impaired CD4

Indexed as

AgingImmune ToleranceImmunosuppression TherapyOvarian NeoplasmsT-Lymphocytes, RegulatoryTumor MicroenvironmentAnimalsFemaleHumansMiceagingimmunosuppressionTregs

Identifiers

PMID42033075
PMCPMC13109645

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.