ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025
[Inflammatory phenotypes in sepsis and the role of vitamin C on the corresponding phenotypes].
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesSepsis is a highly heterogeneous syndrome. This study aims to identify potential phenotypes of sepsis based on commonly used clinical inflammatory parameters and to investigate the impact of vitamin C infusion therapy on survival outcomes in patients with different phenotypes.
methodsPatients with sepsis in the Intensive Care Medical Information Database IV were used as the study population, and the data were randomly divided into two groups of 7:3, which were used for derivation and validation, respectively. In the derivation cohort, the K-means clustering was employed to identify potential phenotypes based on three key feature parameters: white blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), and temperature, and then assess the effect of infused vitamin C treatment on survival outcomes of each phenotype by Kaplan-Meier survival analysis and multifactorial Cox proportional risk model. The same analyses were used in the validation cohort to verify the clustering effect and the heterogeneity of vitamin C efficacy on each phenotype.
resultsA total of 3 771 patients were included in the final analysis, 2 639 in the derivation cohort and 1 132 in the validation cohort. In the derivation cohort, patients with sepsis were categorized into three phenotypes: cluster A (
conclusionsThis study identified three distinct sepsis phenotypes with different clinical characteristics based on three key parameters: WBC, NLR, and temperature. Each phenotype exhibits varying responsiveness to vitamin C therapy, with patients with type A sepsis benefiting from intravenous vitamin C treatment.
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