ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025
[Diagnostic value of combined application of semaphorin 7A, calponin 1 and D-dimer in acute aortic dissection].
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesAcute aortic dissection (AAD) is a life-threatening condition with difficulty in early differential diagnosis, and ideal biomarkers are still lacking. This study aims to investigate the diagnostic value of serum semaphorin 7A (Sema7A), calponin 1 (CNN1), and plasma D-dimer, alone and in combination, in patients with AAD.
methodsA retrospective study was conducted. 90 patients with AAD who visited the Second Xiangya Hospital of Central South University from December 2022 to December 2023 were enrolled, along with 53 patients with acute myocardial infarction (AMI) and 18 patients with acute pulmonary embolism (APE). Additionally, 25 patients without chest pain symptoms or cardiogenic diseases admitted during the same period were included as the control group. General clinical data and laboratory indicators were collected. Serum Sema7A and CNN1 levels were detected using enzyme-linked immunosorbent assay or chemiluminescence immunoassay. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for AAD. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic value of D-dimer, Sema7A, and CNN1.
resultsSerum Sema7A and CNN1 levels in the AAD group were significantly higher than those in the control, AMI, and APE groups (all
conclusionsThe combined application of Sema7A, CNN1, and D-dimer significantly improves the diagnostic performance for AAD and may also serve as an indicative marker for clinical classification, providing new insights for the early differential diagnosis of AAD.
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