ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025
Association of maternal gut microbiota with prenatal depression and the potential mediation effect by plasma tryptophan.
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectivesPrenatal depression is one of the most common psychological disorders during pregnancy, with an incidence of approximately 19.7% in China, and the incidence is showing a significant upward trend. Prenatal depression seriously endangers maternal and infant health, may lead to self-injury and suicide, and has lasting effects on the health of offspring. Studies have shown that gut microbiota imbalance and disruption of the gut-brain axis can affect brain function and behavior and play an important role in the occurrence and development of depression. Significant changes occur in the gut microbiota of pregnant women during pregnancy, which may influence inflammation and metabolism. Gut microbiota play a key role in tryptophan metabolism; however, the mechanisms by which maternal gut microbiota regulate tryptophan metabolism to affect brain function and mood remain unclear. This study aims to clarify the role of plasma tryptophan in the relationship between gut microbiota and prenatal depression in pregnant women based on the gut-brain axis mechanism.
methodsA total of 73 pregnant women were included in the study. The Edinburgh Postnatal Depression Scale (EPDS) was used for assessment. According to the cutoff score (10 points), participants were divided into a prenatal depression group (pregnant women with prenatal depression) and a control group (pregnant women without prenatal depression). Demographic information, fecal samples, and plasma samples were collected. Gut microbiota sequencing was performed using 16S ribosomal RNA (rRNA) sequencing. Amino acid detection in plasma and feces was conducted using ultrahigh performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS). Data were analyzed using SPSS 26.0 and R software, and mediation model analysis was performed using SPSS PROCESS.
resultsThere were no statistically significant differences in α-diversity or β-diversity of gut microbiota between the 2 groups (all
conclusionsDepressive symptoms during pregnancy are associated with the composition of gut microbiota during pregnancy. Tryptophan, as a precursor of serotonin, may play a mediating role in this process, providing new insights for improving prenatal depression through interventions targeting gut microbiota or tryptophan metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.