ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025
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Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
objectivesPostpartum depression (PPD) is a common and serious mental disorder after childbirth, imposing a heavy burden on mothers, infants, and families. Abnormalities in the tryptophan-kynurenine (TRP-KYN) metabolic pathway are considered to be involved in its pathogenesis, but the role of quinolinic acid phosphoribosyltransferase (QPRT), a key downstream enzyme in this pathway, remains unclear. This study aims to explore the association between PPD in women undergoing cesarean section and
methodsA candidate gene association study design was adopted. From January 2024 to June 2025, full-term singleton pregnant women scheduled to undergo elective cesarean section under spinal anesthesia were recruited at the Third Xiangya Hospital of Central South University and Hunan Provincial Maternal and Child Health Hospital. At 42 days postpartum, postpartum depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS). Peripheral blood samples were collected and genomic DNA was extracted. Four
resultsA total of 362 women were ultimately included in the analysis, among whom 29 were diagnosed with PPD, with an incidence of 8.01%. Analysis of general data showed that comorbid hypertension or thyroid disease, inconsistency between neonatal sex and expectation, prenatal depression, prenatal self-harm ideation, domestic violence, poor marital and mother-in-law/daughter-in-law relationships, stressful life events, dissatisfaction with current life status, poor mood during pregnancy, and high stress during pregnancy were all risk factors for PPD in women undergoing cesarean section (all
conclusionsComorbid hypertension or thyroid disease, inconsistency between neonatal sex and expectation, prenatal depression, prenatal self-harm ideation, domestic violence, poor marital and mother-in-law/daughter-in-law relationships, stressful life events, dissatisfaction with current life status, poor mood during pregnancy, high stress during pregnancy, and mutation at the
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