ArticlePaediatric and perinatal epidemiology2026
Neighbourhood Social Vulnerability and Preterm Birth Risk Among Infants With Trisomy 21: A Statewide Analysis.
Article in Paediatric and perinatal epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Race, Place and Preterm Birth.Paediatric and perinatal epidemiology · 2026Article
- Neighbourhood Social Vulnerability and Preterm Birth Risk Among Infants With Trisomy 21: A Statewide Analysis.Paediatric and perinatal epidemiology · 2026Article
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7 authors.
Funding
Abstract
backgroundResiding in socioeconomically vulnerable areas is known to be associated with increased preterm birth (PTB) risk in the general population. However, the relationship between social vulnerability and PTB remains unexplored among infants with trisomy 21, who experience more than twice the PTB rate of the general population.
objectivesThe primary objective was to examine the association between maternal socioeconomic vulnerability, as measured by the SVI, and PTB among infants with trisomy 21.
methodsWe conducted a retrospective cohort study among infants with trisomy 21 born in Texas (1999-2018). We examined the association between neighbourhood vulnerability, measured by Social Vulnerability Index (SVI) quartiles, and PTB utilising data from the Texas Birth Defects Registry. Using Poisson regression, we estimated crude and adjusted risk ratios (RRs) and 95% confidence intervals (CIs), accounting for maternal demographic characteristics and health factors.
resultsOf the 8823 eligible infants included in the analysis, 2269 (25.7%) were born preterm. Maternal residence in the highest vulnerability quartile was associated with an increased risk of PTB (RR 1.17, 95% CI 1.04, 1.32) and moderate to late PTB (RR 1.19, 95% CI 1.05, 1.35), compared to the least vulnerable quartile. In secondary analyses stratified by race/ethnicity, the association with high vulnerability was particularly strong among non-Hispanic Black women (RR 1.44, 95% CI 1.00, 2.07).
conclusionsThese findings underscore the importance of neighbourhood social vulnerability in influencing perinatal health risks, particularly PTB among infants with trisomy 21.
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