ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[LC3-mediated autophagy promotes the occurrence of diabetic gastroparesis by targeting SIRT1].
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesDiabetic gastroparesis (DGP) is a common complication of diabetes mellitus, and its pathogenesis is complex and has not yet been fully elucidated. This study aims to investigate whether microtubule-associated protein 1 light chain 3 (LC3)-mediated autophagy promotes the progression of DGP by targeting sirtuin 1 (SIRT1).
methodsRat gastric smooth muscle cells (GSMCs) were treated with 35 mmol/L glucose to establish an in vitro model of DGP. Autophagy was inhibited using 3-methyladenine (3-MA). The apoptosis rate, trypan blue-positive cell rate, and cell viability were detected. The expression levels of SIRT1, autophagy-related markers (LC3 II, LC3 I, Beclin-1, and p62), and apoptosis-related proteins [B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), and cleaved/non-cleaved caspase-3] were analyzed. The interaction between LC3 II and SIRT1 was validated by co-immunoprecipitation. Six- to 8-week-old SD rats were randomly divided into 4 groups: A normal group, a negative control group, a model group, and a model + 3-MA group (
resultsHigh glucose treatment increased the apoptosis rate and trypan blue-positive cell rate in GSMCs while reducing cell viability. Meanwhile, high glucose also downregulated the expression levels of SIRT1, Bcl-2, and p62, and upregulated the LC3 II/I ratio, Beclin-1, Bax, and cleaved caspase-3 (all
conclusionsHigh glucose can downregulate SIRT1 expression in an LC3 II-dependent manner, thereby inducing apoptosis of GSMCs and promoting the progression of DGP.
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