ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Protective effects of SESN2 on Erastin-induced ferroptosis in renal tubular cells and acute kidney injury].
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesPrevention and treatment of perioperative acute kidney injury (AKI) remain a major focus in clinical practice. This study aims to investigate the role and underlying mechanism of sestrin2 (SESN2) in Erastin-induced ferroptosis of renal tubular cells and AKI in ICR mice.
methodsFor in vitro experiments, human renal proximal tubular epithelial cells (HK-2) stably transfected with lentivirus were divided into three groups: control group, Erastin model group, and SESN2 intervention group. The control group was transfected with empty vector lentivirus (LV-Con). The Erastin model group was transfected with LV-Con and then treated with 10 μmol/L Erastin for 24 h. The SESN2 intervention group was transfected with SESN2-overexpressing lentivirus (LV-SESN2) followed by Erastin treatment. For in vivo experiments, after confirming successful establishment of the Erastin-induced AKI mouse model by measuring serum creatinine (SCr) and blood urea nitrogen (BUN), 18 healthy adult male ICR mice were randomly divided into three groups (
resultsCompared with the in vitro/in vivo control groups, the Erastin model groups and SESN2 intervention groups showed significantly increased levels of LDH, IL-6, TNF-α, MDA, ROS, and Fe
conclusionsSESN2 exerts protective effects against Erastin-induced ferroptosis in renal tubular cells and ferroptosis-related AKI by activating the Nrf2 signaling pathway, upregulating ferroptosis-related molecules GPX4 and FSP1, and inhibiting oxidative stress, lipid peroxidation, and inflammatory responses.
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