ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Effects of spinal cord stimulation implantation on heart rate variability in patients with postherpetic neuralgia].
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesPostherpetic neuralgia (PHN) is a severe and distressing complication in elderly patients with herpes zoster and is associated with increased sympathetic nervous system activity. Spinal cord stimulation (SCS) implantation has been shown to effectively relieve PHN. In recent years, heart rate variability (HRV) analysis, as a reliable and objective indicator of autonomic nervous system (ANS) activity, has been widely used in the assessment of chronic pain. This study aims to investigate the clinical effects of SCS implantation on HRV in patients with PHN and its correlation with pain outcomes.
methodsA total of 28 patients who met the inclusion criteria and were treated in the Department of Pain Medicine, the Third Xiangya Hospital of Central South University between November 2023 and March 2024 were retrospectively included. All patients underwent SCS implantation. HRV parameters before and after SCS implantation were collected, including the standard deviation of all normal-to-normal intervals over 24 hours (SDNN), root mean square of successive differences (RMSSD), standard deviation of successive differences (SDSD), percentage of adjacent normal-to-normal intervals differing by more than 50 milliseconds (PNN50), low-frequency power (LF), high-frequency power (HF), the LF/HF ratio, and total power (TP) within 5 minutes across all frequency bands. Univariate linear regression analysis was performed to explore the correlations among HRV parameters before and after SCS treatment.
resultsAfter SCS implantation, the HRV time-domain indices SDNN, RMSSD, SDSD, and PNN50, as well as the frequency-domain indices LF, HF, and TP, were significantly increased (all
conclusionsPain outcomes in patients with PHN are accompanied by synchronous changes in autonomic nervous system activity. SCS implantation can improve HRV stability in patients with PHN and contribute to better cardiac rhythm regulation. HRV measurement may serve as evidence reflecting ANS activity in patients with PHN.
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