Light-Induced Anion Translocation to Control Helical Folding in an Artificial Communication System.

Indigo M Bekaert, Suchismita Saha, Julia Villalva, David Villarón, Maxime A Siegler, Sander J Wezenberg

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Indigo M BekaertLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.

Suchismita SahaLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.

Julia VillalvaLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.

David VillarónLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.

Maxime A SieglerDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.

Sander J WezenbergLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.ORCID https://orcid.org/0000-0001-9192-3393

Funding

Dutch Research Council OCENW.XS4.188Dutch Research Council VI.Vidi.192.049European Research Council 802830National Roadmap Large-Scale NMR Facility of the Netherlands 184.035.002the 2022 HORIZON-MSCA-PF Program 101108077

6 · The paper itself

Abstract

The processing of incoming signals is key to many biological functions and involves the transfer of chemical messengers. Emulation of such signaling pathways in artificial molecular systems could enable complex, intelligent behavior. Toward this end, we demonstrate that reversible anion release and uptake by a light-responsive synthetic receptor can in turn induce helical folding and unfolding of a complementary secondary receptor, of which a change in circular dichroism (CD) absorption serves as output signal. The helical folding process is thus indirectly controlled by light through communication between the two receptors via anion translocation. This work will trigger development of complex chemical networks in which signals are transmitted, aiding in the creation of smart materials and molecular computers.

Indexed as

AnionsCircular DichroismComputers, MolecularLightAnionsanion recognitionfoldamersmolecular receptorsmolecular switchesstiff‐stilbene

Identifiers

PMID42032879

DOI10.1002/chem.71031

PMCPMC13356402

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.