Evidence map›Paper›PMID 42032764›Full record

ArticleJournal of medical case reports2026

Effects of transcranial direct current stimulation on cognition, depression, and brain activity in a breast-cancer survivor: a case report.

Kedma Anne Lima Gomes Alexandrino, Alana Mara Inácio de Aquino, Sillas Duarte de Melo, Maria Betânia de Andrade César, Amanda Rios Motta, Mathias Weller, Steffany Larissa Galdino Galisa, Jairo Rocha de Faria, Suellen Mary Marinho Dos Santos Andrade

2 registry-linked trialsAbstract readCase Reports
In one paragraph

Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02772185 phase2 / phase3unknown statusnot on this map

Neurostimulation and Cognitive Intervention in Alzheimer's Disease

TypeinterventionalSponsorFederal University of ParaíbaRan2016 to 2019Enrolled60ConditionsAlzheimer's DiseaseArmsactive tDCS, sham tDCS, real CT, placebo CT
NCT04943003 naunknown statusnot on this map

Neurobiological Predictors of Response to Non-invasive Neurostimulation and Genetic Susceptibility to Dementia in Patients With Amnestic Mild Cognitive Impairment (CCL)

TypeinterventionalSponsorSuellen Marinho AndradeRan2021 to 2024Enrolled50ConditionsMild Cognitive ImpairmentArmsTranscranial Direct Current Stimulation (tDCS)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kedma Anne Lima Gomes AlexandrinoPostgraduate Program in Cognitive Neuroscience and Behavior, Federal University of Paraiba, João Pessoa, PB, Brazil. kedmaannekel@gmail.com.ORCID http://orcid.org/0000-0001-6720-011X
Alana Mara Inácio de AquinoPostgraduate Program in Cognitive Neuroscience and Behavior, Federal University of Paraiba, João Pessoa, PB, Brazil.ORCID http://orcid.org/0000-0002-0427-9446
Sillas Duarte de MeloPostgraduate Program in Cognitive Neuroscience and Behavior, Federal University of Paraiba, João Pessoa, PB, Brazil.ORCID http://orcid.org/0000-0002-9406-4800
Maria Betânia de Andrade CésarPostgraduate Program in Cognitive Neuroscience and Behavior, Federal University of Paraiba, João Pessoa, PB, Brazil.ORCID http://orcid.org/0009-0000-8270-2791
Amanda Rios MottaPostgraduate Program in Cognitive Neuroscience and Behavior, Federal University of Paraiba, João Pessoa, PB, Brazil.ORCID http://orcid.org/0009-0006-9872-8914
Mathias WellerPostgraduate Program in Public Health, State University of Paraiba, Campina Grande, PB, Brazil.ORCID http://orcid.org/0000-0002-9653-3690
Steffany Larissa Galdino GalisaPostgraduate Program in Biosciences and Biotechnology in Health - FIOCRUZ/PE, Recife, PE, Brazil.ORCID http://orcid.org/0000-0002-5252-0206
Jairo Rocha de FariaPostgraduate Program in Mathematical and Computational Modeling, João Pessoa, PB, Brazil.ORCID http://orcid.org/0000-0001-6954-4071
Suellen Mary Marinho Dos Santos AndradePostgraduate Program in Cognitive Neuroscience and Behavior, Federal University of Paraiba, João Pessoa, PB, Brazil.ORCID http://orcid.org/0000-0002-6801-0462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCognitive impairment induced by chemotherapy and hormone therapy is a frequent side effect faced by an increasing number of breast-cancer survivors. The literature on the management of this cognitive impairment is still scarce, especially with regard to the application of non-pharmacological methods, such as Transcranial Direct Current Stimulation. CASE PRESENTATION: In this case report, we present a Brazilian Latin American Woman, 71 years, breast-cancer survivor with cognitive complaints after adjuvant treatment and hormone therapy for the Luminal A subtype of the disease. We assessed general cognition, depression, verbal fluency, brain electrical activity in the right and left prefrontal regions of the brain (electrodes Fp1, Fp2, F3, F4, F7 and F8), level of physical activity and oxidative capacity before and after neuromodulation. The patient was submitted to a current of 2 milliamps on the Left Dorsolateral Prefrontal Cortex, three alternated days a week, totaling 12 sessions. Improvements in test scores were observed, with the exception of verbal fluency. Cortical activity, evaluated by electroencephalogram, was also modulated.

conclusionsTranscranial Direct Current Stimulation appears to be a viable alternative to treat cognitive impairment related to antineoplastic treatment.

trial registrationNCT04943003. Registered 29 June 2021, http://www. CLINICALTRIALS: gov/ct2/show/NCT02772185 . Retrospectively registered.

Indexed as

Breast NeoplasmsCancer SurvivorsChemotherapy-Related Cognitive ImpairmentDepressionTranscranial Direct Current StimulationAgedCognitionCognitive EnhancementFemaleHumansTreatment OutcomeBreast neoplasmsCase reportChemotherapy-related cognitive impairmentTranscranial direct current stimulation

Identifiers

PMID42032764
PMCPMC13248344

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.