Evidence map›Paper›PMID 42032594›Full record

Observational studyPediatric rheumatology online journal2026

Morning stiffness duration is associated with physician active joint count in juvenile idiopathic arthritis.

Nikki Ruhof, Sebastiaan J Vastert, Annet van Royen, Marc H A Jansen, Erika van Nieuwenhove, Joost F Swart, Sytze de Roock

Abstract readObservational Study
In one paragraph

Observational study in Pediatric rheumatology online journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nikki RuhofDepartment of Paediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands. n.ruhof@umcutrecht.nl.
Sebastiaan J VastertDepartment of Paediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands.
Annet van RoyenDepartment of Paediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands.
Marc H A JansenDepartment of Paediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands.
Erika van NieuwenhoveDepartment of Paediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands.
Joost F Swart *Department of Paediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands. J.F.Swart@umcutrecht.nl.
Sytze de Roock *Department of Paediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands. s.deroock@umcutrecht.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to assess whether there is an association between morning stiffness duration and the presence of active arthritis in children with Juvenile Idiopathic Arthritis (JIA).

methodsA single-center retrospective observational study was conducted using data from the Wilhelmina Children’s Hospital. Morning stiffness duration was obtained through Juvenile Arthritis Multidimensional Assessment Report (JAMAR) questionnaires completed by patients around the time of their visit to the paediatric rheumatology clinic. Active arthritis was characterized by using the Active Joint Count (AJC) indicated by the pediatric rheumatologist and was defined as an AJC ≥ 1. Associations between morning stiffness and disease activity were investigated with Kruskal-Wallis and Chi-squared tests.

resultsA total of 5421 JAMAR questionnaires from 803 JIA patients who visited the hospital between December 2012 and August 2024 were analysed in this study. A statistically significant association (p < 0.001) was found between morning stiffness duration and the AJC. A diagnostic model with different cut-off values of morning stiffness to predict the presence of active arthritis was constructed, and showed a sensitivity ranging from 0.545 − 0.062 and specificity ranging from 0.755 to 0.990.

conclusionOur findings show the association between active arthritis and the duration of morning stiffness in JIA patients. The association between morning stiffness and active arthritis could potentially be of value in a multivariate model for monitoring patients remotely and determining whether patients need to be assessed by their physician earlier.

Indexed as

Arthritis, JuvenileJointsAdolescentChildChild, PreschoolFemaleHumansMaleRetrospective StudiesSeverity of Illness IndexSurveys and QuestionnairesTime FactorsDisease activityDisease monitoringJuvenile idiopathic arthritisMorning stiffnessPediatric rheumatology

Identifiers

PMID42032594
PMCPMC13262472

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.