ArticleBMC endocrine disorders2026
A High-accuracy and compliance-driven paradigm for pediatric type 2 diabetes screening based on simplified OGTT --- a multicenter study.
Article in BMC endocrine disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundThe incidence of type 2 diabetes (T2D) in children is rising rapidly, yet many cases remain undetected. Conventional diagnostic tools, including fasting glucose, HbA1c, and the gold-standard oral glucose tolerance test (OGTT), have limitations and often show low compliance in pediatric populations. This study aimed to evaluate a simplified OGTT (s-OGTT) with adjusted capillary glucose cut-off values as a novel approach for screening and diagnosing T2D in children and adolescents.
methodsA total of 468 children from four clinical centers in China underwent s-OGTT with capillary glucose testing. Capillary glucose values were compared with venous glucose levels using Bland-Altman analysis. Sensitivity and specificity for diagnosing diabetes and prediabetes were assessed using receiver operating characteristic (ROC) curves.
resultsCapillary glucose levels showed a strong correlation with venous measurements. Based on gold-standard criteria, 37 children were diagnosed with diabetes, 41 with impaired fasting glucose (IFG), and 74 with impaired glucose tolerance (IGT). Using optimized capillary cut-offs tailored for point-of-care testing, the s-OGTT demonstrated excellent diagnostic performance and improved specificity compared with applying conventional venous-based thresholds directly: for diabetes based on fasting glucose (sensitivity 97.56%, specificity 98.40%), diabetes based on 2 h postload glucose (sensitivity 100.00%, specificity 99.67%), IFG (sensitivity 97.60%, specificity 98.30%), and IGT (sensitivity 88.89%, specificity 92.04%). Validation analyses confirmed high agreement between s-OGTT and venous results.
conclusionThe s-OGTT provides a reliable, accurate, and child-friendly approach for diagnosing diabetes and abnormal glucose tolerance. These optimized thresholds enhance diagnostic specificity and support its use for large-scale pediatric screening.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.