ArticleClinical proteomics2026
Plasma proteomics of extracellular vesicles identifies key proteins correlating to postoperative atrial fibrillation after coronary artery bypass surgery.
Article in Clinical proteomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exosomes as a biomarker in postoperative complications: a literature review.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundNew-onset postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) is a major complication and the precise mechanism remains unclear. EVs have become a special intercellular information transmission system secreted from different cells. The present study aimed to identify differentially expressed proteins (DEPs) of the plasma exosomes (Extracellular Vesicles, EVs) from patients with POAF after CABG and explored the pathogenesis of POAF.
methodsLabel-free quantitative LC–MS/MS proteomics analyses were performed to find changes in protein levels proteomic alterations in plasma EVs of patients with POAF (n = 6) after CABG and sinus rhythm (SR, n = 6). The DEPs screened by bioinformatics analysis were validated by parallel reaction monitoring (PRM) quantitative analysis from a new set of plasma samples (POAF n = 9; SR n = 9).
resultsExosomal proteomics identified 51 significant DEPs including 29 up-regulated and 22 down-regulated proteins in POAF group compared to the SR control. Bioinformatics analysis showed that the DEPs were significantly enriched in cysteine and methionine metabolism, Toll-like receptor signaling pathway, AGE-RAGE signaling pathway in diabetic complications and Diabetic cardiomyopathy. The PRM reconfirmed that serum amyloid P-component and Collagen alpha-2(I) chain were significantly down-regulated in POAF group.
conclusionsThis study provides a new insight into the exploration of the pathogenesis of POAF. Abnormally expressed SAP and Collagen alpha-2(I) chain correlate to POAF and might be further explored for their role in the occurrence of POAF. These two proteins in the plasma EVs may be developed as biomarkers for future diagnosis and treatment of POAF in the clinical setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.