Evidence map›Paper›PMID 42032416›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2026

Static and dynamic quantitative sensory testing in chronic pancreatitis: Relation of pain sensitization to patient-reported outcomes and psychiatric comorbidities.

Misbah Unnisa, Søren Schou Olesen, Asbjørn Mohr Drewes, Abdul Rasheed, Madhurya Reddy, Duvvur Nageshwar Reddy, Rupjyoti Talukdar, International Pancreatic Pain Consortium

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Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Misbah UnnisaPancreas Research Group, Asian Institute of Gastroenterology, Gachibowli, Hyderabad 500 032, India.
Søren Schou OlesenDepartment of Gastroenterology and Hepatology, Centre for Pancreatic Diseases and Mech-Sense, Aalborg University Hospital, Aalborg, Denmark.
Asbjørn Mohr DrewesDepartment of Gastroenterology and Hepatology, Centre for Pancreatic Diseases and Mech-Sense, Aalborg University Hospital, Aalborg, Denmark.
Abdul RasheedPancreas Research Group, Asian Institute of Gastroenterology, Gachibowli, Hyderabad 500 032, India.
Madhurya ReddyPancreas Research Group, Asian Institute of Gastroenterology, Gachibowli, Hyderabad 500 032, India.
Duvvur Nageshwar ReddyPancreas Research Group, Asian Institute of Gastroenterology, Gachibowli, Hyderabad 500 032, India.
Rupjyoti TalukdarPancreas Research Group, Asian Institute of Gastroenterology, Gachibowli, Hyderabad 500 032, India. rup_talukdar@yahoo.com.ORCID http://orcid.org/0000-0002-4255-6651
International Pancreatic Pain Consortium

Funding

Aalborg Universitetshospital INPAIN grant
6 · The paper itself

Abstract

backgroundThe etiology of pain in chronic pancreatitis is multi-factorial and includes altered central pain processing. Pancreatic Quantitative Sensory Testing (P-QST) indirectly assesses pain sensitization, yet its clinical significance in relation to psychological comorbidities and quality of life (QoL) remains unclear in Indian populations. The primary objective was to apply an unbiased, data-driven clustering approach using P-QST parameters to stratify patients into centrally sensitized and non-sensitized phenotypes and evaluate their associations with demographic, clinical and patient-reported outcome variables.

methodsThis cross-sectional study enrolled Indian patients with painful chronic pancreatitis between June 2021 and October 2023. We assessed static (pressure pain thresholds and cold pressor endurance) and dynamic (temporal summation and conditioned pain modulation) P-QST parameters to characterize pain processing. Psychological comorbidities, pain catastrophizing and quality of life were measured using validated questionnaires. We compared demographic, clinical and patient-reported outcome variables across pain phenotypes identified from K-median clustering of P-QST parameters.

resultsWe enrolled 264 patients (mean [SD] age- 35.6 [11.0] years, male [%]- 177 [67], idiopathic etiology [%]- 188 [71]). Cluster analysis revealed two distinct pain phenotypes: sensitized (n = 100) and non-sensitized (n = 164). Sensitized patients had lower pressure detection thresholds (2020 vs. 2691 kPa; p < 0.001), shorter cold pressor endurance time (40 s vs. 70 s; p < 0.001) and greater temporal summation (p < 0.001). Demographics and clinical characteristics were comparable between groups, but sensitized patients reported poorer physical (p = 0.037) and social functioning (p = 0.027) and greater fatigue (p = 0.012). No differences were observed for psychological comorbidities.

conclusionUsing an unbiased, data-driven approach, we identified distinct P-QST pain phenotypes in chronic pancreatitis patients, independent of psychological comorbidities, supporting its potential as an unbiased pain assessment tool.

Indexed as

Chronic pancreatitisPainPancreatic quantitative sensory testingPatient-reported outcomesPsychiatric comorbiditiesSensitization

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PMID42032416

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