ArticleBulletin of experimental biology and medicine2026
Dechorionation at an Early Stage of Embryogenesis Modifies the Behavior and Biogenic Amines in the Brain of Adult Zebrafish (Danio rerio).
Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The removal of the cuticular membrane (chorion) in developing Danio rerio embryos was used as a model of mild and long-acting influences to study their consequences for adult D. rerio. We studied the effect of dechorionation 12 h after fertilization on survival, body weight, sex ratio, behavior in the home tank and in the novel tank test, the level of serotonin (5-HT), dopamine (DA), norepinephrine (NE), and their metabolites 5-hydroxyindoleacetic (5-HIAA) and 3,4-dihydroxyphenylalanine acetic (DOPAC) acids in the brain of 6-month-old fish. Dechorionation did not affect survival, body weight, sex ratio, and locomotor activity of adult fish. At the same time, it significantly affected vertical activity of adult fish: the time spent in the upper third of the tank increased in a familiar environment (in a school and in a home tank), but decreased under stressful conditions (novel tank test). Dechorionation did not affect the levels of DA, DOPAC, 5-HT, 5-HIAA, the DOPAC/DA ratio and 5-HIAA/5-HT, but significantly decreased the level of NE in the brain of adult fish. Thus, we have demonstrated the critical role of the chorion for tuning of the brain NE system and the formation of defensive behavior in adult D. rerio: dechorionation causes long-term changes in the brain NE system and in the defensive behavior in the novel tank test in adult fish.
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